Results 81 to 90 of about 7,747 (222)

Trace Element Analysis in Human Neuroblastoma Cell Spheroids Supplemented With ZnCl2 by Micro‐XRF

open access: yesX-Ray Spectrometry, Volume 55, Issue 4, Page 545-552, July/August 2026.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhood, is responsible for ~10% of pediatric cancer deaths and has high potential for metastasis. Metals are extremely important in biological processes, and changes in their levels have been correlated with the development of cancerous growth.
J. E. P. Rosa   +10 more
wiley   +1 more source

Comparative Assessment of Seven Docking Programs on a Nonredundant Metalloprotein Subset of the PDBbind Refined

open access: yes, 2019
Extensive usage of molecular docking for computer-aided drug discovery resulted in development of numerous programs with versatile scoring and posing algorithms.
Süleyman Selim Çınaroğlu (7364234)   +1 more
core   +1 more source

Maturation and Catalysis of a Clade E Carbon Monoxide Dehydrogenase Encoded in a CooCTJ‐Operon From Clostridium pasteurianum BC1

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
This study reveals how Clostridium pasteurianum BC1's clade E carbon monoxide dehydrogenase (CODH‐III) achieves catalytic activity even without its native maturation proteins (CooCTJ), stimulating new interpretations of CODH maturation. Electron paramagnetic resonance (EPR) spectroscopy displays canonical C‐cluster signal.
Maximilian Böhm, Henrik Land
wiley   +1 more source

Nature's Nanotech Warriors: The Role of Metalloproteins and Protein Cages for Environmental Remediation

open access: yesAdvanced Sustainable Systems, Volume 10, Issue 6, June 2026.
Cartoon representation of five major classes of metalloproteins and their brief mechanisms of bioremediation. The five classes include metallothioneins, metal‐precipitating enzymes, P.‐type ATPases, protein cages, and synthetic metalloproteins (de novo‐designed proteins/peptides for selective adsorption). These natural and engineered protein structures
Sian D'Silva   +2 more
wiley   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

open access: yesAdvanced Science, Volume 13, Issue 31, 4 June 2026.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang   +7 more
wiley   +1 more source

Metalloprotein–Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal–Ligand Interactions in a Metalloprotein Active Site

open access: yes, 2016
An ever-increasing number of metalloproteins are being discovered that play essential roles in physiological processes. Inhibitors of these proteins have significant potential for the treatment of human disease, but clinical success of these compounds ...
David P. Martin (1891045)   +2 more
core   +1 more source

Exploring Global Patterns of Trace Metal Limitation as a Regulator of the Distribution of Dominant Marine Phytoplankton Groups

open access: yesGlobal Change Biology Communications, Volume 1, Issue 2, June 2026.
By synthesizing decades of culture data with modern oceanographic datasets, we modelled trace metal limitation of phytoplankton. Our analysis reaffirms the critical role of iron but additionally highlights a significant, growing impact of zinc on the biological pump in future oceans.
Qiong Zhang   +9 more
wiley   +1 more source

Bottom-up design of metalloprotein assemblies with diverse metal coordination motifs and emergent properties [PDF]

open access: yes, 2023
Metal ions are indispensable to biological function, as they are utilized for a myriad of processes encompassing signaling, electron transfer, and catalysis.
Kakkis, Albert
core  

FGF21 Protects Against Hypoxia Injury Through Inducing HSP72 in Cerebral Microvascular Endothelial Cells

open access: yesFrontiers in Pharmacology, 2019
Background: Fibroblast growth factor 21 (FGF21), a member of a family of atypical FGFs, functions as cytokine to control endocrinology and metabolism. Recently, the roles of FGF21 in cardio-cerebral-vascular diseases have been gradually uncovered. In the
Hao-Wei Wang   +6 more
doaj   +1 more source

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