Results 91 to 100 of about 7,747 (222)

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Quantitative Competition Binding of Fluorinated Ligands by Real‐Time 19F In‐Cell NMR to Assess Isoform Selectivity in Human Cells

Magnetic Resonance in Chemistry, Volume 64, Issue 6, Page 584-593, June 2026.
Real‐time in‐cell 19F NMR spectroscopy in a flow NMR bioreactor was used to monitor the binding of fluorinated compounds to three cytosolic carbonic anhydrase isoforms in living human cells. The simultaneous observation of the two ligands allowed for the quantitative ranking of their intracellular affinities by competition binding. This approach allows
Azzurra Costantino, Letizia Barbieri, Simone Giovannuzzi, Alessio Nocentini, Claudiu T. Supuran, Enrico Luchinat   +5 more
wiley   +1 more source

Optical biosensing of nitric oxide using the metalloprotein cytochrome c'

, 1999
The metalloprotein cytochrome c' was extracted and purified from the bacterium Paracoccus denitrificans in order to develop a specific biosensing system for nitric oxide (NO).
Russell, David A., Blyth, David J., Moir, James W.B., Aylott, Jonathan W., Richardson, David J.   +4 more
core   +1 more source

Publisher Correction: Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli

Nature Communications, 2022
Ralf Steinhilper, Gabriele Höff, Johann Heider, Bonnie J. Murphy   +3 more
doaj   +1 more source

Genomic Survey of Carbon Monoxide Dehydrogenases Reveals Their Widespread Distribution in Marine Habitats

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Protein sequence surveys show that nickel‐ and molybdenum/copper‐containing carbon monoxide dehydrogenases (CODHs) are widespread in the ocean. Phylogenetic and genome context analyses reveal that marine CODHs are highly diverse in both evolutionary history and functional organisation.
Nipa Chongdar, Anand Goyal, Samir R. Damare   +2 more
wiley   +1 more source

OsbHLH064, an IVb bHLH Transcription Factor, Regulates Iron Homeostasis and Enhances Grain Fe Accumulation in Rice

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3754-3776, June 2026.
ABSTRACT Iron (Fe) is an essential micronutrient for plant growth and development. The maintenance of Fe homeostasis relies on sophisticated regulatory networks where bHLH transcription factors play a key role. However, how these factors coordinate to regulate this vital process is not fully understood.
Fei Gao, Zhikai Zhu, Kaixin Xue, Zijing Fu, Jitong Yue, Na Zhang, Hongli Zhou, Yaqin Deng, Jing Zhou, Liuhui Kuang, Tao Yan, Lin Li, Christian Dubos, Dezhi Wu   +13 more
wiley   +1 more source

Arbuscular Mycorrhiza Modulates Iron Distribution and Vacuolar Iron Transporter Expression in Tomato, Whereas Iron Limitation Reduces Mycorrhization

Plant, Cell &Environment, Volume 49, Issue 6, Page 3290-3305, June 2026.
ABSTRACT Plants have evolved highly efficient strategies to maintain iron (Fe) homeostasis. In this study, we investigate the impact of arbuscular mycorrhizal (AM) symbiosis on the Fe‐deficiency response and ionomic profile of tomato plants, as well as how Fe availability affects AM symbiosis.
Víctor M. López‐Lorca, Olga López‐Castillo, Mª Jesús Molina‐Luzón, Nuria Ferrol   +3 more
wiley   +1 more source

Femtomolar Zn(II) Affinity in a Peptide-Based Ligand Designed To Model Thiolate-Rich Metalloprotein Active Sites

, 2016
Metal−ligand interactions are critical components of metalloprotein assembly, folding, stability, electrochemistry, and catalytic function. Research over the past 3 decades on the interaction of metals with peptide and protein ligands has progressed from
Alison G. Hyslop (2516389), Brian R. Gibney (1451026), Amit R. Reddi (205858), Michelle L. Kennedy (2516395), Amy K. Petros (2516392)   +4 more
core   +1 more source

An Accurate Metalloprotein-Specific Scoring Function and Molecular Docking Program Devised by a Dynamic Sampling and Iteration Optimization Strategy

, 2015
Metalloproteins, particularly zinc metalloproteins, are promising therapeutic targets, and recent efforts have focused on the identification of potent and selective inhibitors of these proteins.
Junfeng Gu (1612537), Hualiang Jiang (19452), Honglin Li (19441), Xicheng Wang (19451), Fang Bai (1612534), Sha Liao (66846)   +5 more
core   +1 more source

Online immunocapture ICP-MS for the determination of the metalloprotein ceruloplasmin in human serum

BMC Research Notes, 2018
Objective The human copper-protein ceruloplasmin (Cp) is the major copper-containing protein in the human body. The accurate determination of Cp is mandatory for the reliable diagnosis of several diseases.
Bogdan Bernevic, Ahmed H. El-Khatib, Norbert Jakubowski, Michael G. Weller   +3 more
doaj   +1 more source