Results 161 to 170 of about 215,931 (289)

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Causal relationship between matrix metalloproteinases and diabetic retinopathy: A bidirectional two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Qiu X, Yang F, Song Z, Li Y, Huang Q, Zhao S, Gu H.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Expression of matrix metalloproteinases in cerebral amyloid angiopathy-a systematic review. [PDF]

Front Neurol
Gu H, Shi X, Zhang J.
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Matrix metalloproteinases and risk of cardiovascular mortality and morbidity in the United Kingdom: A prospective cohort study with machine learning analysis. [PDF]

Prev Med Rep
Huang J, Jiang H, Lu Y, Ding X, Zhang C, Lin Y, Chen M.   +6 more
europepmc   +1 more source

Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations

Advanced Science, EarlyView.
Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl, Nandan Haloi, Marta Carroni, Shengpan Zhang, Quentin James Sattentau, Erdinc Sezgin, Lucie Delemotte, Rebecca J. Howard   +7 more
wiley   +1 more source

Correction: Cancemi et al. Expression of Alpha-Enolase (ENO1), Myc Promoter-Binding Protein-1 (MBP-1) and Matrix Metalloproteinases (MMP-2 and MMP-9) Reflect the Nature and Aggressiveness of Breast Tumors. Int. J. Mol. Sci. 2019, 20, 3952. [PDF]

Int J Mol Sci
Cancemi P, Buttacavoli M, Roz E, Feo S.
europepmc   +1 more source

miR‐185‐5p Derived From hUC‐MSC Exosomes via Suspension Culture Under Hypoxic Conditions Promotes Scarless Wound Healing in Mice by Precisely Regulating Collagen I/III Regeneration

Advanced Science, EarlyView.
miR‐185‐5p derived from UC‐MSC exosomes via hypoxic suspension culture promotes scarless wound healing in mice by precisely regulating collagen I/III regeneration. Exosomes derived from UC‐MSCs under a three‐dimensional bioreactor and hypoxic conditions were injected into the skin wounds of mice.
Lihua Yang, Yiqun Sun, Qinbiao Yan, Ali Mohsin, Kamran Ashraf, Senyi Gong, Weifeng Li, Touseef Ur Rehman, Yuwen Hu, Jinzhao He, Yu Liu, Meijun Ding, Lin Qi, Meijin Guo, Ke Xue   +14 more
wiley   +1 more source