Results 131 to 140 of about 9,549 (181)
Some of the next articles are maybe not open access.
Inorganic Chemistry, 2004
One of the most intriguing problems in the biological sciences is the question of how to predict protein structure and function based on knowledge of a gene sequence. While significant progress has been made toward this goal during the past decade, fundamental challenges remain, such as understanding important post-translational modifications.
Bren, Kara L. +2 more
openaire +3 more sources
One of the most intriguing problems in the biological sciences is the question of how to predict protein structure and function based on knowledge of a gene sequence. While significant progress has been made toward this goal during the past decade, fundamental challenges remain, such as understanding important post-translational modifications.
Bren, Kara L. +2 more
openaire +3 more sources
Design of functional metalloproteins [PDF]
Nature, 2009 Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new metalloproteins. Doing so not only can reveal hidden structural features that may be missing from studies of native metalloproteins and their ...
Nicholas M Marshall
exaly +3 more sources
Current Opinion in Biotechnology, 1996
The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
openaire +2 more sources
The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
openaire +2 more sources
2013
Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
openaire +2 more sources
Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
openaire +2 more sources
NMR Spectroscopy of Paramagnetic Metalloproteins
ChemBioChem, 2005AbstractThis article deals with the solution structure determination of paramagnetic metalloproteins by NMR spectroscopy. These proteins were believed not to be suitable for NMR investigations for structure determination until a decade ago, but eventually novel experiments and software protocols were developed, with the aim of making the approach ...
Roberta Pierattelli +2 more
exaly +4 more sources
Metalloproteins in the evolution of photosynthesis
Biosystems, 1981Certain metalloproteins are common to all photosynthetic electron transfer chains. These include soluble proteins such as ferredoxins and cytochromes of the c2 type, and membrane-bound components such as cytochrome b, c1 and the Rieske iron-sulphur protein.
R, Cammack, K K, Rao, D O, Hall
openaire +2 more sources
Predicting cracks in metalloproteins
Nature Machine Intelligence, 2019Loss-of-function mutations in metal-binding proteins are heavily implicated with numerous diseases, and identifying such ‘cracks’ will be valuable to biologists and medical doctors in the study and treatment of disease. A deep learning approach has been developed to tackle this challenging task.
Yuan Liu, Chu Wang
openaire +1 more source
Metalloproteins and neuronal death
Metallomics, 2010Neurodegenerative diseases include Alzheimer's and Parkinson's disease that are very common and other diseases that are notorious but occur less often such as Creutzfeldt-Jakob disease. In each case a protein is closely linked to the pathology of these diseases. These proteins include alpha-synuclein, the prion protein and Aβ.
openaire +2 more sources
Metalloproteins and metal sensing
Nature, 2009Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells.
Kevin J, Waldron +3 more
openaire +2 more sources