Results 1 to 10 of about 11,336 (207)

Rational Design of Artificial Metalloproteins and Metalloenzymes with Metal Clusters

Molecules, 2019
Metalloproteins and metalloenzymes play important roles in biological systems by using the limited metal ions, complexes, and clusters that are associated with the protein matrix.
Ying-Wu Lin
exaly   +3 more sources

Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites

Pharmaceuticals, 2023
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others.
Dimitrios Moianos, Georgia-Myrto Prifti, Maria Makri, Grigoris Zoidis   +3 more
doaj   +1 more source

Fantastic [FeFe]-Hydrogenases and Where to Find Them

Frontiers in Microbiology, 2022
[FeFe]-hydrogenases are complex metalloenzymes, key to microbial energy metabolism in numerous organisms. During anaerobic metabolism, they dissipate excess reducing equivalents by using protons from water as terminal electron acceptors, leading to ...
Simone Morra
doaj   +1 more source

Evaluation of Dilution Susceptibility Testing Methods for Aztreonam in Combination with Avibactam against Enterobacterales

Microbiology Spectrum, 2022
As multidrug and pan-resistance among Enterobacterales continue to increase, there is an urgent need for more therapeutic options to treat these infections.
C. J. Kelley, A. Kennedy-Mendez, O. N. Walser, M. T. Thwaites, F. F. Arhin, C. M. Pillar, D. A. Hufnagel   +6 more
doaj   +1 more source

Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase

IUCrJ, 2020
Enzymes are catalysts of biological processes. Significant insight into their catalytic mechanisms has been obtained by relating site-directed mutagenesis studies to kinetic activity assays. However, revealing the detailed relationship between structural
Jin Kyun Kim, Cheol Lee, Seon Woo Lim, Jacob T. Andring, Aniruddha Adhikari, Robert McKenna, Chae Un Kim   +6 more
doaj   +1 more source

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

IUCrJ, 2022
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies.
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M. E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C. F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kevin L. Weiss, Jonathan A. R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi, Michael A. Hough   +25 more
doaj   +1 more source

Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions

Metabolites, 2020
The critical CO2 hydration reaction to bicarbonate and protons is catalyzed by carbonic anhydrases (CAs, EC 4.2.1.1). Their physiological role is to assist the transport of the CO2 and HCO3− at the cellular level, which will not be ensured by the ...
Sonia Del Prete, Andrea Angeli, Cynthia Ghobril, Julien Hitce, Cécile Clavaud, Xavier Marat, Claudiu T. Supuran, Clemente Capasso   +7 more
doaj   +1 more source

Metalloproteomics: Principles, challenges and applications to neurodegeneration

Frontiers in Aging Neuroscience, 2013
Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process.
Blaine Russell Roberts, Amber eLothian, Dominic James Hare, Dominic James Hare, Colin L. Masters, Timothy M. Ryan, Rudolf eGrimm   +6 more
doaj   +1 more source

Artificial Metalloenzymes for Enantioselective Catalysis Based on the Biotin-Avidin Technology

CHIMIA, 2008
Artificial metalloenzymes, based on the incorporation of a biotinylated catalytically active organometallic moiety within streptavidin, offer an attractive alternative to homogeneous, heterogeneous and enzymatic catalysis.
Jincheng Mao, Thomas R. Ward
doaj   +1 more source

Computational Understanding of the Selectivities in Metalloenzymes

Frontiers in Chemistry, 2018
Metalloenzymes catalyze many different types of biological reactions with high efficiency and remarkable selectivity. The quantum chemical cluster approach and the combined quantum mechanics/molecular mechanics methods have proven very successful in the ...
Wen-Jie Wei, Hui-Xia Qian, Wen-Juan Wang, Rong-Zhen Liao   +3 more
doaj   +1 more source