Results 11 to 20 of about 23,761 (232)
Current Medicinal Chemistry, 2019 Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine.
Blanquart, Christophe +5 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Carbonic anhydrases (CAs) are a zinc metalloenzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton, pivotal for a wide range of biological processes. CAs are involved in numerous pathologies and thus represent valuable
Andrea Angeli +4 more
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The Geometry of the Catalytic Active Site in [FeFe]-hydrogenases is Determined by Hydrogen Bonding and Proton Transfer [PDF]
, 2019 [FeFe]-hydrogenases are efficient metalloenzymes that catalyze the oxidation and evolution of molecular hydrogen, H2. They serve as a blueprint for the design of synthetic H2-forming catalysts.
Apfel, Ulf-Peter +11 more
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Nickel-dependent metalloenzymes [PDF]
Archives of Biochemistry and Biophysics, 2014 This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase.
Jodi L, Boer +2 more
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Fantastic [FeFe]-Hydrogenases and Where to Find Them
Frontiers in Microbiology, 2022 [FeFe]-hydrogenases are complex metalloenzymes, key to microbial energy metabolism in numerous organisms. During anaerobic metabolism, they dissipate excess reducing equivalents by using protons from water as terminal electron acceptors, leading to ...
Simone Morra
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Peptide-Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics [PDF]
, 2019 We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet
Koksch, Beate, Mikolajczak, Dorian J.
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Metalloproteomics: Principles, challenges and applications to neurodegeneration
Frontiers in Aging Neuroscience, 2013 Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process.
Blaine Russell Roberts +6 more
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Artificial Metalloenzymes for Enantioselective Catalysis Based on the Biotin-Avidin Technology
CHIMIA, 2008 Artificial metalloenzymes, based on the incorporation of a biotinylated catalytically active organometallic moiety within streptavidin, offer an attractive alternative to homogeneous, heterogeneous and enzymatic catalysis.
Jincheng Mao, Thomas R. Ward
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Zinc(II)-methimazole complexes: synthesis and reactivity [PDF]
, 2015 The tetrahedral S-coordinated complex [Zn(MeImHS)(4)](ClO4)(2), synthesised from the reaction of [Zn(ClO4)(2)] with methimazole (1-methyl-3H-imidazole-2-thione, MeImHS), reacts with triethylamine to yield the homoleptic complex [Zn(MeImS)(2)] (MeImS ...
Aragoni M C +9 more
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Computational Understanding of the Selectivities in Metalloenzymes
Frontiers in Chemistry, 2018 Metalloenzymes catalyze many different types of biological reactions with high efficiency and remarkable selectivity. The quantum chemical cluster approach and the combined quantum mechanics/molecular mechanics methods have proven very successful in the ...
Wen-Jie Wei +3 more
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