Results 1 to 10 of about 222,813 (114)
BK channel activators and their therapeutic perspectives
Frontiers in Physiology, 2014 The large conductance calcium- and voltage- activated K+ channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important
Bo Hjorth Bentzen
exaly +3 more sources
Aza-peptides: expectations and reality [PDF]
Proceedings of the Estonian Academy of Sciences, 2022 The replacement of the α-carbon atom in an α-amino acid structure by a nitrogen atom yields alkylcarbazic acids, also known as α-aza amino acids.
Anu Ploom +4 more
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A Beginner’s Guide to Osmoprotection by Biostimulants
Plants, 2021 Water is indispensable for the life of any organism on Earth. Consequently, osmotic stress due to salinity and drought is the greatest threat to crop productivity.
David Jiménez-Arias +7 more
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Therapeutic Strategies to Activate p53
Pharmaceuticals, 2022 The p53 protein has appropriately been named the “guardian of the genome”. In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of ...
Angelo Aguilar, Shaomeng Wang
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Biomedicines, 2022 Pulmonary arterial hypertension (PAH) is a disease that progress over time and is defined as an increase in pulmonary arterial pressure and pulmonary vascular resistance that frequently leads to right-ventricular (RV) failure and death.
Linh Ho +4 more
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Revista Ingeniería de Construcción, 2020 Portland cement is considered an excellence building material. This is due mainly to its high performance, its good quality/price ratio and the raw materials from which it is made can be found almost everywhere in the world.
M. Torres-Carrasco, F. Puertas
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New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds
Pharmaceuticals, 2022 NAD+-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer.
Giulia Bononi +11 more
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The Angiogenic Balance and Its Implications in Cancer and Cardiovascular Diseases: An Overview
Medicina, 2022 Angiogenesis is the process of developing new blood vessels from pre-existing ones. This review summarizes the main features of physiological and pathological angiogenesis and those of angiogenesis activation and inhibition.
Cătălina Ionescu +7 more
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Frontiers in Immunology, 2022 Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains two CARD domains, an RNA helicase domain, and a C-terminal domain.
Hao Wang +9 more
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Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives
Molecules, 2022 Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases.
Giulia Bononi +9 more
doaj +1 more source