Results 1 to 10 of about 46,462 (246)

Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension

BMC Research Notes, 2021
Objectives In pulmonary arterial hypertension (PAH), right ventricular (RV) dysfunction develops via mechanisms involving oxidative stress. Moderate and chronic red wine (RW) consumption reduces oxidative stress and confers cardioprotection but its ...
Patrick Diaba-Nuhoho, Martin Cour, Nkanyiso Hadebe, David Marais, Sandrine Lecour, Dee Blackhurst   +5 more
doaj   +1 more source

Anthracycline-induced cardiotoxicity: targeting high-density lipoproteins to limit the damage?

Lipids in Health and Disease, 2022
Doxorubicin (DOX) is an anthracycline antibiotic frequently used against a wide range of cancers, including breast cancer. Although the drug is effective as a treatment against cancer, many patients develop heart failure (HF) months to years following ...
Carmelita Abrahams, Nicholas J. Woudberg, Sandrine Lecour   +2 more
doaj   +1 more source

Ubiquinol-cytochrome c reductase core protein 1 may be involved in delayed cardioprotection from preconditioning induced by diazoxide. [PDF]

PLoS ONE, 2017
This study aimed to use long-term diazoxide treatment to establish a loss-of-cardioprotection model and then perform proteomics analysis to explore which proteins of mitochondrial inner membrane (MIM) are potentially involved in delayed cardioprotection.
Zonghong Long, Guangyou Duan, Hong Li, Tingting Yi, Xiaoxiao Wu, Feng Chen, Zhuoxi Wu, Yuqi Gao   +7 more
doaj   +1 more source

Compositions and Functions of Mitochondria-Associated Endoplasmic Reticulum Membranes and Their Contribution to Cardioprotection by Exercise Preconditioning

Frontiers in Physiology, 2022
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are important components of intracellular signaling and contribute to the regulation of intracellular Ca2+/lipid homeostasis, mitochondrial dynamics, autophagy/mitophagy, apoptosis, and ...
Yuhu Lv, Lin Cheng, Fenglin Peng
doaj   +1 more source

Dynamic Regulation of Cysteine Oxidation and Phosphorylation in Myocardial Ischemia–Reperfusion Injury

Cells, 2021
Myocardial ischemia–reperfusion (I/R) injury significantly alters heart function following infarct and increases the risk of heart failure. Many studies have sought to preserve irreplaceable myocardium, termed cardioprotection, but few, if any ...
Kevin M. Casin, John W. Calvert
doaj   +1 more source

Cardioprotective mechanisms of mitochondria-targeted S-nitrosating agent and adenosine triphosphate-sensitive potassium channel opener are mutually exclusiveCentral MessagePerspective

JTCVS Open, 2021
Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD, Jie Wang, MD, Ana Karen Velez, MD, Alejandro Suarez-Pierre, MD, Kathleen C. Clement, MD, Jie Dong, Krisztian Sebestyen, MS, Joseph K. Canner, MHS, Michael P. Murphy, PhD, Jennifer S. Lawton, MD   +9 more
doaj   +1 more source

HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB

Journal of Investigative Surgery, 2022
Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He, Dong-Xiao Wang, Jian-Jun Meng, Xiao-Fang Cheng, Qi Bi, Guo-Qiang Zhong, Rong-Hui Tu   +6 more
doaj   +1 more source

Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Molecules, 2018
Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high.
Frederic Nduhirabandi, Gerald J. Maarman   +1 more
doaj   +1 more source

Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling

JCI Insight, 2023
Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by its uptake into cells by equilibrative nucleoside transporters (ENTs ...
Wei Ruan, Jiwen Li, Seungwon Choi, Xinxin Ma, Yafen Liang, Ragini Nair, Xiaoyi Yuan, Tingting W. Mills, Holger K. Eltzschig   +8 more
doaj   +1 more source

A brief overview of cardioprotective signaling [PDF]

Arhiv za farmaciju
Cardioprotection is defined as the intrinsic ability of cardiac tissue to withstand challenges like ischemia-reperfusion and different metabolic stresses.
Jovanović Aleksandar
doaj   +1 more source