Results 11 to 20 of about 21,822 (212)
Hexokinases and cardioprotection [PDF]
Journal of Molecular and Cellular Cardiology, 2015 As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of ...
Calmettes, Guillaume +5 more
openaire +4 more sources
JTCVS Open, 2021 Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD +9 more
doaj +1 more source
Ageing, sex, and cardioprotection [PDF]
British Journal of Pharmacology, 2020 Translation of cardioprotective interventions aimed at reducing myocardial injury during ischaemia–reperfusion from experimental studies to clinical practice is an important yet unmet need in cardiovascular medicine. One particular challenge facing translation is the existence of demographic and clinical factors that influence the pathophysiology of ...
Marisol Ruiz‐Meana +8 more
openaire +3 more sources
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB
Journal of Investigative Surgery, 2022 Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He +6 more
doaj +1 more source
Melatonin in Heart Failure: A Promising Therapeutic Strategy?
Molecules, 2018 Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high.
Frederic Nduhirabandi +1 more
doaj +1 more source
JCI Insight, 2023 Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by its uptake into cells by equilibrative nucleoside transporters (ENTs ...
Wei Ruan +8 more
doaj +1 more source
A brief overview of cardioprotective signaling [PDF]
Arhiv za farmacijuCardioprotection is defined as the intrinsic ability of cardiac tissue to withstand challenges like ischemia-reperfusion and different metabolic stresses.
Jovanović Aleksandar
doaj +1 more source
Cardioprotection by Adiponectin [PDF]
Trends in Cardiovascular Medicine, 2006 Obesity-related disorders are closely associated with the pathogenesis of cardiovascular disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated in obese individuals. Hypoadiponectinemia has been identified as an independent risk factor for type 2 diabetes, coronary artery disease, and hypertension, and experimental ...
Noriyuki, Ouchi +2 more
openaire +2 more sources
South African Journal of Science, 2019 A number of cardioprotective interventions have been identified throughout the years, and these include the use of natural antioxidants in sources like rooibos (Aspalathus linearis) tea.
Gerald J. Maarman
doaj +1 more source
Cardiovascular Diabetology, 2019 Background The mechanisms underlying increased mortality in patients with diabetes and admission hyperglycemia after an acute coronary syndrome may involve reduced capacity for cardioprotection.
Steen Buus Kristiansen +7 more
doaj +1 more source