Results 21 to 30 of about 31,146 (236)
Sevoflurane and cardioprotection [PDF]
British Journal of Anaesthesia, 2008 The authors hypothesize that the cardioprotective effect of sevoflurane administered throughout CABG operation may be time- and dose-dependent.
L. Siracusano +3 more
openaire +3 more sources
Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1-methyl-L-histidine. [PDF]
Adv Sci (Weinh)Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Jiang K +7 more
europepmc +2 more sources
Hexokinases and cardioprotection [PDF]
Journal of Molecular and Cellular Cardiology, 2015 As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of ...
Calmettes, Guillaume +5 more
openaire +4 more sources
The role of existing and novel cardiac biomarkers for cardioprotection
, 2007 Cardioprotection is an all-encompassing term for physico-biochemical or therapeutic interventions which slow or ameliorate the progression of cardiomyocyte necrosis. There are a number of established and novel biomarkers to assess coronary artery disease
Gaze, D.C.
core +5 more sources
Cells, 2021 Myocardial ischemia–reperfusion (I/R) injury significantly alters heart function following infarct and increases the risk of heart failure. Many studies have sought to preserve irreplaceable myocardium, termed cardioprotection, but few, if any ...
Kevin M. Casin, John W. Calvert
doaj +1 more source
JTCVS Open, 2021 Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD +9 more
doaj +1 more source
Ageing, sex, and cardioprotection [PDF]
British Journal of Pharmacology, 2020 Translation of cardioprotective interventions aimed at reducing myocardial injury during ischaemia–reperfusion from experimental studies to clinical practice is an important yet unmet need in cardiovascular medicine. One particular challenge facing translation is the existence of demographic and clinical factors that influence the pathophysiology of ...
Marisol Ruiz‐Meana +8 more
openaire +3 more sources
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB
Journal of Investigative Surgery, 2022 Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He +6 more
doaj +1 more source
Melatonin in Heart Failure: A Promising Therapeutic Strategy?
Molecules, 2018 Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high.
Frederic Nduhirabandi +1 more
doaj +1 more source
Cardioprotection by Adiponectin [PDF]
Trends in Cardiovascular Medicine, 2006 Obesity-related disorders are closely associated with the pathogenesis of cardiovascular disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated in obese individuals. Hypoadiponectinemia has been identified as an independent risk factor for type 2 diabetes, coronary artery disease, and hypertension, and experimental ...
Noriyuki, Ouchi +2 more
openaire +2 more sources