Results 21 to 30 of about 21,822 (212)
M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p. [PDF]
PLoS ONE, 2012 The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury.
Zhenyu Pan +14 more
doaj +1 more source
Biomedical and Biotechnology Research Journal, 2022 Background: Diabetes decreased cardioprotective potential of ischemic postconditioning (IPOC), atrial natriuretic peptide (ANP) induced the cardioprotection against ischemic-reperfusion (I/R) injury. The present study has been designed to investigate the
Garima Gupta +4 more
doaj +1 more source
Role of Macrophages in Cardioprotection [PDF]
International Journal of Molecular Sciences, 2019 Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known that non-resolving inflammation results in atherosclerotic conditions, which are responsible for a host of downstream pathologies including thrombosis, myocardial infarction (MI), and neurovascular events.
Jonathan Yap +4 more
openaire +4 more sources
Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes [PDF]
Korean Journal of Anesthesiology, 2011 During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury.
Jin Mo Kim, Young Ho Jang, Jun Kim
doaj +1 more source
Acta Pharmaceutica Sinica B, 2021 Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury (MIRI). NRF2, the endogenous antioxidant regulator, might provide therapeutic benefits.
Hao Zeng +8 more
doaj +1 more source
Circulation, 2008 Over the past 2 to 3 decades, several phenomena have been identified that provide powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: myocardial hibernation that is related to stunning,2 ischemic preconditioning,3 delayed or second-window ischemic preconditioning,4 ischemic postconditioning,5 and their ...
Gerd Heusch +2 more
openaire +1 more source
Journal of Diabetes Research, 2016 The effect of sevoflurane postconditioning (sevo-postC) cardioprotection is compromised in diabetes which is associated with increased oxidative stress. We hypothesized that antioxidant N-Acetylcysteine may enhance or restore sevo-postC cardioprotection ...
Jiefu Lin +6 more
doaj +1 more source
Identifying the Source of a Humoral Factor of Remote (Pre)Conditioning Cardioprotection.
PLoS ONE, 2016 Signalling pathways underlying the phenomenon of remote ischaemic preconditioning (RPc) cardioprotection are not completely understood. The existing evidence agrees that intact sensory innervation of the remote tissue/organ is required for the release ...
Svetlana Mastitskaya +5 more
doaj +1 more source
TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury. [PDF]
PLoS ONE, 2014 Recent work shows that cooling protection after mouse cardiac arrest and cardiomyocyte ischemia is mediated by Akt activation. The PI3K p85 subunit can either augment or inhibit Akt activation depending on its binding to p110 or PTEN respectively.
Xiangdong Zhu +9 more
doaj +1 more source
Doxorubicin-induced cardiotoxicity and risk factors
International Journal of Cardiology: Heart & VasculatureDoxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumours and hematologic malignancies. Although useful in the treatment of cancers, the benefit of DOX is limited due to its cardiotoxic effect that is
Carl Belger +3 more
doaj +1 more source