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Neutrophils and myocardial reperfusion injury
Pharmacology & Therapeutics, 1996Ischaemia induces an acute inflammatory response in myocardial tissue with an early phase of neutrophil accumulation, which is accelerated by reperfusion. In experimental models, interventions that deplete neutrophils or inhibit their function cause a significant reduction in myocardial infarct size. These cells, therefore, may exacerbate tissue injury
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Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement.
Journal of the American College of CardiologyDespite impressive improvements in the care of patients with ST-segment elevation myocardial infarction, mortality remains high. Reperfusion is necessary for myocardial salvage, but the abrupt return of flow sets off a cascade of injurious processes that
F. Welt +8 more
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Unresolved issues in myocardial reperfusion injury
Cardiovascular Pathology, 2010While the basic pathobiology of myocardial ischemic injury and reperfusion has been determined over the last 50 years, there are important, unresolved, or at least not completely elucidated, issues in the field. These include the relative contributions of different modes of cell injury and death to evolving myocardial infarcts; interactions of ...
Louis Maximilian, Buja +1 more
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Myocardial ischemia and reperfusion injury
Cardiovascular Pathology, 2005Myocardial ischemic injury results from severe impairment of coronary blood supply and produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, a detailed understanding is now available of the complexity of the response of the myocardium to an ischemic insult.
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Peroxynitrite in Myocardial Ischemia-Reperfusion Injury
Heart Failure Reviews, 2002Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion.
Manoj M, Lalu +2 more
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Life Science, 2021
AIMS Reperfusion therapy is the most common and effective treatment against ischemic heart disease (IHD), but the process inflicts massive ischemia/reperfusion (I/R) injury for which no treatment exists.
Chaoqun Nie +6 more
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AIMS Reperfusion therapy is the most common and effective treatment against ischemic heart disease (IHD), but the process inflicts massive ischemia/reperfusion (I/R) injury for which no treatment exists.
Chaoqun Nie +6 more
semanticscholar +1 more source
Reperfusion injury, stunning and myocardial viability
Australian and New Zealand Journal of Medicine, 1993Abstract:Recent experimental data suggest that current thrombolytic strategies may not yet have achieved their full potential for myocardial salvage. In fact, reperfusion may result in microvascular and myocardial cellular injuries. These may translate into transient loss of contractile function (‘myocardial stunning’), and possibly contribute to the ...
A, Tonkin, R, Chan
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Phytomedicine
BACKGROUND Cardiovascular disease is the main cause of death and disability, with myocardial ischemia being the predominant type that poses a significant threat to humans.
Shuo Zhang +8 more
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BACKGROUND Cardiovascular disease is the main cause of death and disability, with myocardial ischemia being the predominant type that poses a significant threat to humans.
Shuo Zhang +8 more
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Role of epigenetic regulation in myocardial ischemia/reperfusion injury.
Pharmacological Research, 2021Nowadays acute myocardial infarction (AMI) is a serious cardiovascular disease threatening the human life and health worldwide. The most effective treatment is to quickly restore coronary blood flow through revascularization.
Ke-mei Wang +4 more
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1999
Abstract Early in the history of cardiac surgery, it was recognized that some patients who underwent technically successful operations suffered from a syndrome of low cardiac output in the early postoperative period. It was also apparent that the perioperative mortality was increased in these patients. Autopsy and clinical studies in the
Robert C Gorman, Timothy J Gardner
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Abstract Early in the history of cardiac surgery, it was recognized that some patients who underwent technically successful operations suffered from a syndrome of low cardiac output in the early postoperative period. It was also apparent that the perioperative mortality was increased in these patients. Autopsy and clinical studies in the
Robert C Gorman, Timothy J Gardner
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