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Myocardial reperfusion injury [PDF]
European Heart Journal Supplements, 2002 Post-ischaemic reperfusion carries an injurious component that may partly counteract the beneficial effects of reflow; this component has been termed ‘reperfusion injury’. Principal mediators of this phenomenon are oxygen radicals and neutrophils. Oxygen radicals, generated in large amounts upon reflow, induce oxidative tissue damage and modulate ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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Lethal Myocardial “Reperfusion Injury” [PDF]
Journal of Thrombosis and Thrombolysis, 1997 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/48021/1/11239_2004_Article_255436 ...
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Platelets in Myocardial Ischemia/Reperfusion Injury
Hämostaseologie, 2022 AbstractCoronary artery disease, including myocardial infarction (MI), remains a leading cause of global mortality. Rapid reperfusion therapy is key to the improvement of patient outcome but contributes substantially to the final cardiac damage. This phenomenon is called “ischemia/reperfusion injury (IRI).” The underlying mechanisms of IRI are complex ...
Schanze, Nancy +4 more
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On Circadian Variation of Myocardial Reperfusion Injury [PDF]
Circulation Research, 2012 See related article, pages 105–110 In 1729, Jean Jacques d'Ortous de Marian, a French scientist, made the fascinating observation that plants that unfolded their leaves when exposed to sunlight (presumably to increase photosynthesis, a process that had not yet been discovered) continued to rhythmically unfold their leaves in the morning and fold them ...
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Role of autophagy in myocardial reperfusion injury
Frontiers in Bioscience, 2010 While autophagy is induced by myocardial ischemia/reperfusion, it is unclear whether autophagy is detrimental or beneficial to myocardial survival during ischemia/reperfusion. Isolated rat hearts were subjected to 30 min regional ischemia followed by 2 h of reperfusion.
Yulan, Jin +4 more
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Myocardial reperfusion injury: a new view [PDF]
Cardiovascular Research, 2004 Acute coronary occlusion resulting in myocardial infarction is the main mechanism by which coronary artery disease reduces survival and leads to deterioration of the quality of life, and the extent of cell death is the main determinant of survival in patients with acute myocardial infarction.
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Anaesthesia and myocardial ischaemia/reperfusion injury [PDF]
British Journal of Anaesthesia, 2009 Anaesthetists are confronted on a daily basis with patients with coronary artery disease, myocardial ischaemia, or both during the perioperative period. Therefore, prevention and ultimately adequate therapy of perioperative myocardial ischaemia and its consequences are the major challenges in current anaesthetic practice.
J, Frässdorf, S, De Hert, W, Schlack
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Myocardial ischemia-reperfusion injury and the influence of inflammation
Trends in Cardiovascular Medicine, 2023 Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to ischemia in the corresponding myocardial territory which generally results in myocardial necrosis. Without restoration of coronary perfusion, myocardial scar formation will cause adverse remodelling of the myocardium and heart failure.
Algoet, Michiel +6 more
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Down’s syndrome and myocardial reperfusion injury
Journal of the Saudi Heart Association, 2011 Down syndrome is known to be an independent risk factor for mortality after surgical repair of congenital heart anomalies. It is also associated with neurodegenerative disease and accelerated aging. The mechanism of the latter features has been attributed to abnormal handling of oxygen-free radicals as well as mitochondrial dysfunction.
Kumar, Susheel, Jonas, Richard
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Curcumin attenuates myocardial ischemia-reperfusion injury
Oncotarget, 2017 Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world.Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated.The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ...
Liu, Kun +8 more
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