Results 31 to 40 of about 188,975 (215)

Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial Ischemia/Reperfusion Injury

The Scientific World Journal, 2012
Background. Revascularization of infarcted myocardium results in release of inflammatory cytokines mediating myocardial reperfusion injury and heart failure. Blockage of inflammatory pathways dampens myocardial injury and reduces infarct size.
Christina Grothusen, Angelika Hagemann, Tim Attmann, Jan Braesen, Ole Broch, Jochen Cremer, Jan Schoettler   +6 more
doaj   +1 more source

Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities

World Journal of Cardiology, 2018
Acute myocardial infarction (AMI) is the leading cause of death worldwide. Its associated mortality, morbidity and complications have significantly decreased with the development of interventional cardiology and percutaneous coronary angioplasty (PCA ...
Jaime González-Montero, robert brito, A. Gajardo, R. Rodrigo   +3 more
semanticscholar   +1 more source

Intramyocardial Hemorrhage and the “Wave-front” of Reperfusion Injury Compromising Myocardial Salvage

Journal of the American College of Cardiology, 2022
Background: Reperfusion therapy for acute MI is lifesaving. However, the benefit of reperfusion therapy can be paradoxically diminished due to reperfusion injury, which can increase MI size.
Ting Liu, A. Howarth, Yinyin Chen, Anand R. Nair, Hsin-Jung Yang, Daoyuan Ren, R. Tang, J. Sykes, M. Kovacs, D. Dey, P. Slomka, J. Wood, R. Finney, M. Zeng, F. Prato, J. Francis, D. Berman, P. Shah, Andreas Kumar, R. Dharmakumar   +19 more
semanticscholar   +1 more source

Myocardial ischemia – reperfusion injury

Zaporožskij Medicinskij Žurnal, 2023
Aim. To summarize and broaden the idea about mechanisms of acute coronary insufficiency development and pathophysiological features of myocardial reperfusion injury.
S. V. Salo, V. O. Shumakov, S. S. Shpak, V. V. Tokhtarov   +3 more
doaj   +1 more source

Pathobiology of Myocardial Ischemia and Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, and Clinical Applications

Cardiology in Review, 2022
This review presents an integrated approach to the analysis of myocardial ischemia and reperfusion injury and the modulating influence of myocardial conditioning during the evolution of acute myocardial infarction (AMI) and other clinical settings ...
Lawrence Buja
semanticscholar   +1 more source

The role of gut microbiota in myocardial ischemia-reperfusion injury

Frontiers in Cardiovascular Medicine
Myocardial ischemia-reperfusion injury denotes the pathological damage resulting from the restoration of blood flow and oxygen supply following acute coronary artery occlusion.
Xin Chen, Xin Chen, Xin Chen, Lu Ye, Xin Zou, Yuan Zhou, Chan Peng, Rui Huang, Rui Huang, Rui Huang   +9 more
doaj   +1 more source

Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury

Oxidative Medicine and Cellular Longevity, 2021
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane ...
Wei-Kun Zhao, Yao Zhou, Tongtong Xu, Qi Wu   +3 more
semanticscholar   +1 more source

Different types of cell death and their interactions in myocardial ischemia–reperfusion injury

Cell Death Discovery
Myocardial ischemia–reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow is restored to the heart tissue following ischemia-induced damage.
Bin Du, Qiang Fu, Qing Yang, Ye Yang, Rui Li, Xu Yang, Qing Yang, Shuo Li, Jinwei Tian, Huibin Liu   +9 more
semanticscholar   +1 more source

Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41

International Journal on Biological Sciences, 2022
Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and its molecular mechanism is urgently needed. Studies have shown that the intestinal flora plays an important regulatory role in cardiovascular injury, but the
Fan Deng, Liang Zhang, Han Wu, Y. Chen, Wenqian Yu, Ronghui Han, Yuan Han, Xiao-Qi Zhang, Qishun Sun, Zebin Lin, Yu Wang, Yong-pan Liu, Jingyi Chen, Ke-xuan Liu, Jingjuan Hu   +14 more
semanticscholar   +1 more source

Pyroptosis: Novel Targets in Molecular Mechanisms and Drug Therapy Research for Myocardial Ischemia Reperfusion Injury

Reviews in Cardiovascular Medicine
Myocardial ischemia-reperfusion injury is a significant complication of reperfusion therapy and a primary cause of mortality in patients with acute myocardial infarction.
Dong Zhang, Hui Wu, ShengYu Gong, Gang Zhou, Qing Zhang, Song Li, Wei Yang   +6 more
doaj   +1 more source