Results 11 to 20 of about 188,975 (215)

Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Identifying new therapeutic targets for preventing the myocardial ischemia–reperfusion injury would have profound implications in cardiovascular medicine.
Pavel Zhabyeyev, Brent McLean, Wesam Bassiouni, Robert Valencia, Manish Paul, Ahmed M. Darwesh, John M. Seubert, Saugata Hazra, Gavin Y. Oudit   +8 more
doaj   +1 more source

Opportunities and challenges of pain-related myocardial ischemia-reperfusion injury

Frontiers in Physiology, 2022
Pain is one of the most serious problems plaguing human health today. Pain is not an independent pathophysiological condition and is associated with a high impact on elevated disability and organ dysfunction.
Wenhua Jiang, Yue Yin, Xiaoming Gu, Zihui Zhang, Heng Ma, Heng Ma   +5 more
doaj   +1 more source

Deubiquitinase OTUD5 as a Novel Protector against 4‐HNE‐Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Advancement of science, 2023
Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number of patients experience high mortality due to myocardial ischemia‐reperfusion (MI/R) injury.
Lulu Liu, J. Pang, Dandan Qin, Ruochuan Li, D. Zou, Kai Chi, Wenxiao Wu, H. Rui, Huaxiang Yu, Wenyong Zhu, Kai Liu, Xuting Wu, Jinxin Wang, Ping Xu, Xiaoshuai Song, Yihai Cao, Jiali Wang, Feng Xu, L. Xue, Yuguo Chen   +19 more
semanticscholar   +1 more source

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Journal of Cardiothoracic Surgery, 2021
The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the ...
Fuwen Huang, Jingting Mai, Jingwei Chen, Yinying He, Xiaojun Chen   +4 more
doaj   +1 more source

Propofol has delayed myocardial protective effects after a regional ischemia/reperfusion injury in an in vivo rat heart model [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundIt is well known that propofol protects myocardium against myocardial ischemia/reperfusion injury in the rat heart model. The aim of this study was to investigate whether propofol provides a protective effect against a regional myocardial ...
Il Woo Shin, In Seok Jang, Seung-Hwa Lee, Ji-Seok Baik, Kyeong-Eon Park, Ju-Tae Sohn, Heon Keun Lee, Young Kyun Chung   +7 more
doaj   +1 more source

Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential

Antioxidants, 2023
Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted, leading to cardiac damage and massive loss of viable cardiomyocytes.
J. Francisco, D. D. Del Re
semanticscholar   +1 more source

Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism of its occurrence involves multiple complex metabolic pathways and signaling pathways.
Hao Tian, Xiaoshuai Zhao, Yuxi Zhang, Zhongyuan Xia   +3 more
semanticscholar   +1 more source

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
doaj   +1 more source

Intravenous Transplantation of an Ischemic-specific Peptide-TPP-mitochondrial Compound Alleviates Myocardial Ischemic Reperfusion Injury

ACS Nano, 2023
It is known that mitochondrial dysfunction is a critical factor involved in myocardial ischemia–reperfusion injury. Mitochondrial transplantation has been suggested as an effective therapeutic strategy to protect against myocardial ischemia–reperfusion ...
Xiaolei Sun, Hang Chen, Rifeng Gao, Yanan Qu, Ya Huang, Ning Zhang, Shiyu Hu, Fan Fan, Y. Zou, K. Hu, Zhaoyang Chen, Junbo Ge, A. Sun   +12 more
semanticscholar   +1 more source

Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. [PDF]

PLoS ONE, 2017
The protective effects of ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated. Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial
Shuang-Wei Zhang, Yu Liu, Fang Wang, Jiao Qiang, Pan Liu, Jun Zhang, Jin-Wen Xu   +6 more
doaj   +1 more source