Results 11 to 20 of about 1,258,622 (242)

Lipoxygenase-derived eicosanoids in myocardial ischaemia-reperfusion injury: the role of sensory C-fibres and TRPV1 [PDF]

, 2010
PhDIt is well established that the 12-lipoxygenase (12-LOX) pathway of arachidonic acid (AA) metabolism is stimulated within the myocardium by episodes of ischaemia, and there is considerable evidence showing that eicosanoids derived via this pathway ...
Goddard, Alison
core   +4 more sources

Q50, an Iron-Chelating and Zinc-Complexing Agent, Improves Cardiac Function in Rat Models of Ischemia/Reperfusion-Induced Myocardial Injury [PDF]

, 2013
Background: Reperfusion of ischemic myocardium may contribute to substantial cardiac tissue damage, but the addition of iron chelators, zinc or zinc complexes has been shown to prevent heart from reperfusion injury.
Faragó, Nóra, Hirschberg Kristóf, Korkmaz S, Merkely Béla Péter, Radovits, Tamás, Hirschberg, Kristóf, Barnucz E, Karck Matthias, Szabó Gábor, Fábián Gabriella, Gyuris Márió, Puskás László G., Loganathan Sivakkanan, Radovits Tamás, Weymann Alexander, Szabó, Csaba, Fábián, Gabriella, Loganathan, Sivakkanan, Karck, Matthias, Merkely, Béla, Kanizsai Iván, Faragó Nóra, Hegedűs Péter, Korkmaz, Sevil, Li Shiliang, Hegedűs, Péter, Gyuris, Márió, Szabó Csaba, Zubarevich Alina, Li, Shiliang, Puskás, László G., Korkmaz Sevil, Ózsvári, Béla, Zubarevich, Alina, Weymann, Alexander, Li S, Merkely Béla, Barnucz, Enikő, Puskás László, Kanizsai, Iván, Szabó, Gábor, Barnucz Enikő, Loganathan S, Ózsvári Béla   +43 more
core   +2 more sources

Endothelin and the ischaemic heart [PDF]

, 2005
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
McCabe, C., Kane, K.A., Wainwright, C.L.
core   +8 more sources

Reperfusion Injury after Acute Myocardial Infarction [PDF]

, 2022
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. Primary percutaneous coronary intervention (PPCI) is the gold standard treatment for patients presenting with ST-segment elevation myocardial infarction (STEMI ...
Ishikawa, Tetsuya, Koshikawa, Yuuri, Nakahara, Shiro, Yamada, Kota, Mizutani, Yukiko, Itabashi, Yuji, Taguchi, Isao, Sato, Hirotsugu, Hori, Yuichi, Kobayashi, Sayuki, Ukaji, Tomoaki, Nakamura, Hidehiko   +11 more
core   +1 more source

SR-A3 Promotes USP18-Mediated deISGylation of STING to Protect Against Myocardial Ischemia-Reperfusion Injury. [PDF]

Adv Sci (Weinh)
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Han Y, Miao G, Zhao Y, Du Z, Lu K, Xiao C, Xian A, Duanmu J, Zhou Z, Chen J, Zhang L, Zhai C, Xu Y, Li Z, Shen X, Shi S, Chen J, Mei S, Fang Y, Zheng L, Zhang L, Wang Y, Huang W, Dong E, Xian X.   +24 more
europepmc   +2 more sources

Celastrol-Loaded Conductive Hydrogel Mitigates Myocardial Ischemia-Reperfusion Injury and Restores Electrophysiological Function. [PDF]

Adv Sci (Weinh)
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Wang S, Chen S, Li C, Cheng H, Jiao J, Peng X, Zhang Y, Sun W, Zhang F, Cui C, Chen M.   +10 more
europepmc   +2 more sources

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury [PDF]

, 1997
Objective: Polymorphonuclear leukocytes (PMN), retained in the microvascular bed, can contribute to postischemic myocardial reperfusion injury. Since a beneficial effect of ACE-inhibition on reperfusion injury has been reported, we investigated the ...
Weber, Christian, Messmer, Konrad, Habazettl, Helmut, Kupatt, Christian, Gerlach, Eckehart, Zahler, Stefan, Becker, Bernhard F., C Kupatt   +7 more
core   +1 more source

Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) dampens hepatic ischemia-reperfusion injury [PDF]

, 2011
Recent work has demonstrated that the formation of platelet neutrophil complexes (PNCs) affects inflammatory tissue injury. Vasodilator-stimulated phosphoprotein (VASP) is crucially involved into the control of PNC formation and myocardial reperfusion ...
Birk, Philipp, Morote-Garcia, Julio C., Rosenberger, Peter, Peter Rosenberger, Eldh, Therese, Andreas Straub, Klemens König, Philipp Birk, Therese Eldh, König, Klemens, Julio C Morote-Garcia, Straub, Andreas, Köhler, David, David Köhler   +13 more
core   +2 more sources

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide [PDF]

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
core   +1 more source

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI) [PDF]

, 2014
AimDespite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI.
Singh, Satnam, Lim, Pitt O, Christopher Neil (433186), Bruce, M, Broadhurst, Paul, Madhani, Melanie; id_orcid, Nishat Siddiqi (7733786), Schwarz, Konstantin, Awsan, Noman, Jansen, Else, McPherson, Gladys, Dawson, Dana, Slattery, Elaine, Struthers, Allan, McDonald, Alison, Rhodes, Jonathan, Neil, Christopher, Toff, William, Bruce, M., Garg, Deepak, Siddiqi, N, Firoozi, Sami, Kaski, JC, Madhani, M., Nicholas Boon (7733804), Kaski, Juan-Carlo, Sofia Papadopoulou (7733789), Horowitz, J, Bennett, Lorraine, Horowitz, J., Frenneaux, Michael, Boon, N., Bruce, Margaret, Hildick-Smith, David, Lim, P., Neil, C., Nightingale, Peter, Pitt O. Lim (7733795), Graeme MacLennan (275485), Hannah, Andrew, Feelisch, M., Melanie Madhani (3851305), Roberts, Elved, Dawson, D, David Hildick-Smith (7733798), Madhani, M, Kaski, Juan Carlos, Lim, PO, Stewart, Andrew, Cooter, Nina, Rajendran, Sharmalar, Horowitz, John, Lang, Chim, Papadopoulou, Sofia A., NIAMI investigators, Jagpal, Baljit, Cotton, S, Siddiqi, N., Gonzalvez, Fatima, Feelisch, Martin, Madhani, Melanie, Boon, Nicholas, Nicholas Bunce (7733792), Brown, Sue, Roy, David, Bunce, N., Bunce, N, Papadopoulou, S, Dawson, D., Frenneaux, M., Michael Frenneaux (3576296), Davidson, Tracey, Siddiqi, Nishat, Dargie, Henry, Feelisch, M, Neil, C, Dana Dawson (7020656), Hildick-Smith, D., Frenneaux, M, Hildick-Smith, D, Bunce, Nicholas, NIAMI investigators (7733810), Cotton, Seonaidh, Seonaidh Cotton (503485), de Belder, Adam, Papadopoulou, S., Black, Marilyn, Kaski, J., Hogg, Duncan, Dautov, Rustem, Metcalfe, Malcolm, Bogle, Richard, Cotton, S., Boon, N, Martin Feelisch (358503), John Horowitz (7733801), Margaret Bruce (782483), Lim, Pitt O., MacLennan, G, Cotton, Seonaidh Claire, Juan Carlos Kaski (7733807), Maclennan, Graeme, Papadopoulou, Sofia, MacLennan, G.   +103 more
core   +1 more source