Results 21 to 30 of about 188,975 (215)

Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition

Frontiers in Pharmacology, 2023
Reperfusion is essential for ischemic myocardium but paradoxically leads to myocardial damage that worsens cardiac functions. Ferroptosis often occurs in cardiomyocytes during ischemia/reperfusion (I/R).
Weixia Chen, Yue Zhang, Zuoxiang Wang, Ming-yue Tan, Jia Lin, Xiao-shun Qian, Hongxia Li, Tingbo Jiang   +7 more
semanticscholar   +1 more source

Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination

Balkan Medical Journal, 2023
Background: In myocardial ischemia-reperfusion injury, myocardial damage is aggravated when blood perfusion is restored in myocardial infarction. Ubiquitin-specific protease 11 (USP11), a deubiquitinating enzyme, could remove the ubiquitination of ...
Yunfei Zhang, Juledezi Hailati, Xiaoyun Ma, Hasidaer Midilibieke, Zhiqiang Liu   +4 more
doaj   +1 more source

Long noncoding RNA FTX ameliorates hydrogen peroxide-induced cardiomyocyte injury by regulating the miR-150/KLF13 axis

Open Life Sciences, 2020
Myocardial reperfusion is an effective therapy for acute myocardial infarction (AMI). However, ischemia/reperfusion (I/R) injury following myocardial reperfusion is a significant limitation for AMI treatment.
Zhang Yamin, Fan Xiaoying, Yang Hua
doaj   +1 more source

Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Acute myocardial infarction remains the leading cause of death in humans. Timely restoration of blood perfusion to ischemic myocardium remains the most effective strategy in the treatment of acute myocardial infarction, which can significantly reduce ...
Tianqing Zhang, Wenxu Deng, Ying Deng, Yao Liu, Sijie Xiao, Yanfang Luo, Wang Xiang, Qi He   +7 more
semanticscholar   +1 more source

Cardioprotective action of aprepitant in a rat model of ischemia-reperfusioninduced myocardial injury: role of PI3K-AkT-GSK-3β-HIF-1α signaling pathway

Acta Cirúrgica Brasileira, 2022
Purpose: The present study explored the role and mechanism involved in aprepitant-induced cardioprotective effects in rat model of ischemia-reperfusion injury.
Mei Qian, Yang Liu
doaj   +1 more source

Novel roles of κ-opioid receptor in myocardial ischemia-reperfusion injury [PDF]

PeerJ
Acute heart attack is the primary cause of cardiovascular-related death worldwide. A common treatment is reperfusion of ischemic tissue, which can cause irreversible damage to the myocardium.
Wen Zhang, Qi Zhang, Yali Liu, Jianming Pei, Na Feng   +4 more
doaj   +2 more sources

A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury

Pharmaceuticals, 2022
Myocardial infarction is the leading cause of cardiovascular mortality, with myocardial injury occurring during ischemia and subsequent reperfusion (IR).
Nir Qvit, Amanda J. Lin, Aly Elezaby, Nicolai P. Ostberg, Juliane C. Campos, Julio C. B. Ferreira, Daria Mochly-Rosen   +6 more
doaj   +1 more source

Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review)

Experimental and Therapeutic Medicine, 2022
Myocardial infarction is one of the primary causes of mortality in patients with coronary heart disease worldwide. Early treatment of acute myocardial infarction restores blood supply of ischemic myocardium and decreases the mortality risk. However, when
Jianfeng He, Danyong Liu, Lixian Zhao, Dongcheng Zhou, J. Rong, Liangqing Zhang, Zhengyuan Xia   +6 more
semanticscholar   +1 more source

An Injectable Dual‐Function Hydrogel Protects Against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium

Advancement of science, 2022
Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective strategy for treating MI due to the multiple physiological functions of NO ...
Tian Hao, Meng Qian, Yating Zhang, Qi Liu, Adam C. Midgley, Yangping Liu, Yongzhe Che, Jingli Hou, Qiang Zhao   +8 more
semanticscholar   +1 more source

Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundUlinastatin has anti-inflammatory properties and protects organs from ischemia/reperfusion-induced injury. The aim of this study was to investigate whether ulinastatin provides a protective effect on a regional myocardial ischemia/reperfusion ...
Il-Woo Shin, In-Seok Jang, Seung-Min Lee, Kyeong-Eon Park, Seong-Ho Ok, Ju-Tae Sohn, Heon-Keun Lee, Young-Kyun Chung   +7 more
doaj   +1 more source