Results 41 to 50 of about 31,146 (236)
Acta Pharmaceutica Sinica B, 2021 Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury (MIRI). NRF2, the endogenous antioxidant regulator, might provide therapeutic benefits.
Hao Zeng +8 more
doaj +1 more source
Methods and pharmaceutical compositions for the cardioprotection [PDF]
, 2014 The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in
B. Galeh-Marzban +8 more
core +4 more sources
Circulation, 2008 Over the past 2 to 3 decades, several phenomena have been identified that provide powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: myocardial hibernation that is related to stunning,2 ischemic preconditioning,3 delayed or second-window ischemic preconditioning,4 ischemic postconditioning,5 and their ...
Gerd Heusch +2 more
openaire +1 more source
Identifying the Source of a Humoral Factor of Remote (Pre)Conditioning Cardioprotection.
PLoS ONE, 2016 Signalling pathways underlying the phenomenon of remote ischaemic preconditioning (RPc) cardioprotection are not completely understood. The existing evidence agrees that intact sensory innervation of the remote tissue/organ is required for the release ...
Svetlana Mastitskaya +5 more
doaj +1 more source
Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection [PDF]
, 2019 Acute myocardial infarction (AMI) and the heart failure (HF) that often complicates this condition, are among the leading causes of death and disability worldwide.
Bøtker, Hans Erik +7 more
core +1 more source
Journal of Diabetes Research, 2016 The effect of sevoflurane postconditioning (sevo-postC) cardioprotection is compromised in diabetes which is associated with increased oxidative stress. We hypothesized that antioxidant N-Acetylcysteine may enhance or restore sevo-postC cardioprotection ...
Jiefu Lin +6 more
doaj +1 more source
TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury. [PDF]
PLoS ONE, 2014 Recent work shows that cooling protection after mouse cardiac arrest and cardiomyocyte ischemia is mediated by Akt activation. The PI3K p85 subunit can either augment or inhibit Akt activation depending on its binding to p110 or PTEN respectively.
Xiangdong Zhu +9 more
doaj +1 more source
Cardioprotective functions of HDLs [PDF]
Journal of Lipid Research, 2014 Multiple human population studies have established the concentration of high density lipoprotein (HDL) cholesterol as an independent, inverse predictor of the risk of having a cardiovascular event. Furthermore, HDLs have several well-documented functions with the potential to protect against cardiovascular disease.
Kerry-Anne, Rye, Philip J, Barter
openaire +2 more sources
Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen [PDF]
, 2014 The effects of hypoxia on gene expression have been vigorously studied, but possible effects of small changes in oxygen tension have never been addressed.
Sukhodub, Andriy +9 more
core +1 more source
Doxorubicin-induced cardiotoxicity and risk factors
International Journal of Cardiology: Heart & VasculatureDoxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumours and hematologic malignancies. Although useful in the treatment of cancers, the benefit of DOX is limited due to its cardiotoxic effect that is
Carl Belger +3 more
doaj +1 more source