Results 21 to 30 of about 262,207 (307)
TWO-PHASE MIXING IN TRACTOR DIESEL: THEORY, EXPERIMENT, TECHNICAL SOLUTIONS [PDF]
Volga Region Farmland, 2022 The article is devoted to the problem of improving the power, fuel-economic and environmental performance of tractor diesel engines due to the organization and practical implementation of mixing in two phases. The first phase is carried out in the intake
A.P. Ukhanov +3 more
doaj +1 more source
Journal of Biomedical Photonics & Engineering, 2021 Real–time digestion of type I collagen molecules by bacterial collagenase from Clostridium histolyticum has been monitored using Dynamic Light Scattering method. Time dependencies for translation diffusion coefficient (Dt) and hydrodynamic radius (RH) on
Irina A. Sergeeva +3 more
doaj +1 more source
Sirtuin activators as an anti-aging intervention for longevity [PDF]
Exploration of Drug ScienceSirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis ...
Puja Sah, Anita K. Rai, Donkupar Syiem
doaj +1 more source
Transcriptional activators and activation mechanisms [PDF]
Protein & Cell, 2007 Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 The β-class carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Burkholderia pseudomallei, BpsCAβ, that is responsible for the tropical disease melioidosis was investigated for its activation with natural and non-natural amino acids and ...
Daniela Vullo +7 more
doaj +1 more source
Nanodelivery of cGAS-STING activators for tumor immunotherapy [PDF]
, 2022 Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote antitumor immunity.
Huang, L, Guo, J
core +1 more source
Virtual Screening in the Identification of Sirtuins’ Activity Modulators
Molecules, 2022 Sirtuins are NAD+-dependent deac(et)ylases with different subcellular localization. The sirtuins’ family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins
Elena Abbotto +5 more
doaj +1 more source
Keeping Transcriptional Activators under Control [PDF]
, 2006 Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this ...
Sikder, Devanjan +2 more
core +1 more source
Natural AMPK Activators in Cardiovascular Disease Prevention
, 2021 Cardiovascular diseases (CVD), as a life-threatening global disease, is receiving worldwide attention. Seeking novel therapeutic strategies and agents is of utmost importance to curb CVD.
Mohammadi, P. +7 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The activation of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacteria Brucella suis and Francisella tularensis with amine and amino acids was investigated. BsuCA 1 was sensitive to activation with amino acids and amines, whereas FtuCA was
Andrea Angeli +7 more
doaj +1 more source