Results 31 to 40 of about 262,207 (307)

Insights on the Modulation of SIRT5 Activity: A Challenging Balance

Molecules, 2022
SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging.
Matteo Mori, Giulia Cazzaniga, Fiorella Meneghetti, Stefania Villa, Arianna Gelain   +4 more
doaj   +1 more source

Comparison of the Kinetic Parameters of Alternative Oxidases From Trypanosoma brucei and Arabidopsis thaliana—A Tale of Two Cavities

Frontiers in Plant Science, 2021
The alternative oxidase (AOX) is widespread in plants, fungi, and some protozoa. While the general structure of the AOX remains consistent, its overall activity, sources of kinetic activation and their sensitivity to inhibitors varies between species. In
Fei Xu, Alice C. Copsey, Luke Young, Mario R. O. Barsottini, Mary S. Albury, Anthony L. Moore   +5 more
doaj   +1 more source

Quantitative Comparison of HSF1 Activators

, 2022
The heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones.
Steurer, Christoph, Wegrostek, Christina, Kerschbaum, Sarah, Gabriel, Stefan, Hallaj, Ali, Ortner, Viktoria, Czerny, Thomas, Riegel, Elisabeth   +7 more
core   +1 more source

Silica Fume as Precursor in the Development of Sustainable and High-Performance MK-Based Alkali-Activated Materials Reinforced With Short PVA Fibers

Frontiers in Materials, 2019
Alkali-activated materials (AAM) are currently the subject of increasing interest and research, mainly due to the possibility of reducing the carbon dioxide (CO2) emissions in their production when compared to Portland cement (PC) and still achieve ...
Raquel P. Batista, Ana Carolina C. Trindade, Paulo H. R. Borges, Flávio de A. Silva   +3 more
doaj   +1 more source

Regulation of nuclear factor erythroid-2-related factor 2 as a potential therapeutic target in intracerebral hemorrhage

Frontiers in Molecular Neuroscience, 2022
Hemorrhagic stroke can be categorized into several subtypes. The most common is intracerebral hemorrhage (ICH), which exhibits significant morbidity and mortality, affecting the lives of millions of people worldwide every year.
Yuan Zhang, Wanpeng Yu, Yingying Liu, Wenguang Chang, Man Wang, Lei Zhang   +5 more
doaj   +1 more source

Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5

, 2022
Sirtuins are NAD+-dependent protein deacylases involved in metabolic regulation and aging-related diseases. Specific activators for seven human Sirtuin isoforms would be important chemical tools and potential therapeutic drugs.
Palmeira, Carlos M., Michele Aventaggiato, Fioravanti, Rossella, Weiss, Sandra, Carlos M. Palmeira, Antonello Mai, Garg, Neha, Mai, Antonello, David Sinclair, Steegborn, Clemens, Clemens Steegborn, David B. Lombard, Suenkel, Benjamin, Tafani, Marco, Neha Garg, Surinder Kumar, Kumar, Surinder, Lombard, David B., Sergio Valente, Tuo Hu, Aventaggiato, Michele, Sandra Weiss, Elisabetta Di Bello, Marco Tafani, Hu, Tuo, Sinclair, David, João A. Amorim, Amorim, Joao A., Singh, Pankaj K., Benjamin Suenkel, Clemens Zwergel, Di Bello, Elisabetta, Valente, Sergio, Zwergel, Clemens, Rossella Fioravanti, Pankaj K. Singh   +35 more
core   +2 more sources

Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N′-aryl-N-hydroxy-ureas

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The inhibition of α-, β-, γ-, and δ-class carbonic anhydrases (CAs, EC 4.2.1.1) from bacteria (Vibrio cholerae and Porphyromonas gingivalis) and diatoms (Thalassiosira weissflogii) with a panel of N’-aryl-N-hydroxy-ureas is reported. The α-/β-CAs from V.
Emanuela Berrino, Murat Bozdag, Sonia Del Prete, Fatmah A. S. Alasmary, Linah S. Alqahtani, Zeid AlOthman, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source

Pharmacological Targeting of Phosphoinositide Lipid Kinases and Phosphatases in the Immune System: Success, Disappointment and New Opportunities

Frontiers in Immunology, 2012
The predominant expression of the γ and δ isoforms of PI3K in cells of hematopoietic lineage prompted speculation that inhibitors of these isoforms could offer opportunities for selective targeting of PI3K in the immune system in a range of immune ...
Stephen Geoffrey Ward, Matthew David Blunt   +1 more
doaj   +1 more source

Formulation of Alkali-Activated Slag Binder Destined for Use in Developing Countries

Applied Sciences, 2020
Worldwide cement production is around 4.2 billion tons, and the fabrication of one ton of ordinary Portland cement emits around 900 kg of CO2. Blast furnace slag (BFS) is a byproduct used to produce alkali-activated materials (AAM).
Nabil Bella, Edwin Gudiel, Lourdes Soriano, Alba Font, María Victoria Borrachero, Jordi Paya, José Maria Monzó   +6 more
doaj   +1 more source

Improved Composting Through Fermented Activators [PDF]

, 2013
Composts are important components in improving or restoring soil fertility. However, it takes long time for it to prepare and buying starter cultures of beneficial microorganisms to speed-up composting can be expensive.
Pet Roey L. Pascual
core   +1 more source