Results 21 to 30 of about 10,865 (201)
Mysteries of Metals in Metalloenzymes [PDF]
Accounts of Chemical Research, 2014 Natural metalloenzymes are often the most proficient catalysts in terms of their activity, selectivity, and ability to operate at mild conditions. However, metalloenzymes are occasionally surprising in their selection of catalytic metals, and in their responses to metal substitution.
Valdez, Crystal E +3 more
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A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells
Angewandte Chemie, EarlyView.A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim +7 more
wiley +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Carbonic anhydrases (CAs) are a zinc metalloenzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton, pivotal for a wide range of biological processes. CAs are involved in numerous pathologies and thus represent valuable
Andrea Angeli +4 more
doaj +1 more source
Dual Activation of H2 and CO2 by a Pincer‐Type Ni–Zn Heterobimetallic Complex
Angewandte Chemie, EarlyView.A bimetallic Ni−Zn complex performs sequential activations of H2 (1 equiv) and CO2 (2 equiv). This bimetallic cooperativity is attributed to the weak Lewis acidic nature of Zn(II), which promotes fluxional ligand binding. Namely, an X‐type ligand at Ni, where X is hydride or formate, toggles between two different binding modes: bridging Zn(μ‐X)Ni and ...
Krishnendu Dey +3 more
wiley +2 more sources
Vitamin Bs as Potent Anticancer Agents through MMP-2/9 Regulation
Frontiers in Bioscience-LandmarkIn recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies.
Ha Vy Thi Vo, Namdoo Kim, Hyuck Jin Lee
doaj +1 more source
Journal of Lipid Research, 2007 manganese lipoxygenase (Mn-LO) oxygenates 18:3n-3 and 18:2n-6 to bis-allylic 11S-hydroperoxy fatty acids, which are converted to 13R-hydroperoxy fatty acids.
Mirela Cristea, Ernst H. Oliw
doaj +1 more source
, 2014 Citation: 'metalloenzyme' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.MT06765 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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mBioNitrogenases are the only enzymes able to fix gaseous nitrogen into bioavailable ammonia and hence are essential for sustaining life. Catalysis by nitrogenases requires both a large amount of ATP and electrons donated by strongly reducing ferredoxins or ...
Holly Addison +3 more
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Carbonic Anhydrases: Role in pH Control and Cancer
Metabolites, 2018 The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Y. Mboge +3 more
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Nickel-dependent metalloenzymes [PDF]
Archives of Biochemistry and Biophysics, 2014 This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase.
Jodi L, Boer +2 more
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