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Computational Design of Metalloproteins
2014A number of design strategies exist for the development of novel metalloproteins. These strategies often exploit the inherent symmetry of metal coordination and local topology. Computational design of metal binding sites in flexible regions of proteins is challenging as the number of conformational degrees of freedom is significantly increased ...
Avanish S, Parmar +2 more
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Metalloproteins and metal sensing
Nature, 2009Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells.
Kevin J, Waldron +3 more
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Metalloproteins and neuronal death
Metallomics, 2010Neurodegenerative diseases include Alzheimer's and Parkinson's disease that are very common and other diseases that are notorious but occur less often such as Creutzfeldt-Jakob disease. In each case a protein is closely linked to the pathology of these diseases. These proteins include alpha-synuclein, the prion protein and Aβ.
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2015
Preface: Metalloproteins play essential critical functional roles in enzymatically catalyzing reactions difficult to achieve without metals, in signal transduction, and in storage and transport of proteins constituting over 1/3 of the proteome of living organisms.
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Preface: Metalloproteins play essential critical functional roles in enzymatically catalyzing reactions difficult to achieve without metals, in signal transduction, and in storage and transport of proteins constituting over 1/3 of the proteome of living organisms.
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FTIR Spectroscopy of Metalloproteins
2014Absorption of infrared radiation by proteins gives important information about their structure and function. The most intense infrared bands correspond to the overlap of all the peptide bond absorption. Additionally, in many metalloproteins their prosthetic groups have intrinsic ligands or bind substrates/inhibitors that absorb intensively in the ...
Oscar, Gutiérrez-Sanz +2 more
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EXAFS: a probe for metalloproteins
Nature, 1990X-ray absorption spectroscopy provides a method for studying the local environment around a metal atom in a protein.
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Advances in Research on Metalloproteins
2014Metal ions play essential roles in biological processes. Ions such as K(+) and Na(+) are important in ion transport, and Mg(2+), Ca(2+), and Zn(2+) are important chelators in many processes, including phosphotransfer and harvesting of light for energy metabolism.
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