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Engineering and design in the bioelectrochemistry of metalloproteins
Current Opinion in Structural Biology, 2001Engineered metalloproteins offer interesting systems for electrochemical studies of protein structure/function and their applications in nanobiotechnology. Scanning probe microscopy and cyclic voltammetry of engineered metalloproteins and electrodes have proved to be a powerful combination of tools contributing to the field of bioelectrochemistry.
GILARDI, Gianfranco +2 more
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Computational Design of Metalloproteins
2014A number of design strategies exist for the development of novel metalloproteins. These strategies often exploit the inherent symmetry of metal coordination and local topology. Computational design of metal binding sites in flexible regions of proteins is challenging as the number of conformational degrees of freedom is significantly increased ...
Avanish S. Parmar +2 more
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2013
Metalloproteins catalyze numerous biological reactions ranging from photosynthesis, respiration, nitrogen fixation to signal transduction and complex chemical reactions. It is thus not surprising that metalloproteins account for almost one-half of the total number of proteins in nature.
Kyle D. Miner +7 more
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Metalloproteins catalyze numerous biological reactions ranging from photosynthesis, respiration, nitrogen fixation to signal transduction and complex chemical reactions. It is thus not surprising that metalloproteins account for almost one-half of the total number of proteins in nature.
Kyle D. Miner +7 more
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Copper and iron metalloproteins
Trends in Biochemical Sciences, 1976The most important oxidases and all oxygen carriers are copper and/or iron metalloproteins. Unique metabolic devices have evolved to utilize these essential metals effectively.
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Molecular dynamics simulations of metalloproteins
Current Opinion in Chemical Biology, 2003Molecular dynamics simulations are now commonly applied to metalloproteins, despite the challenges introduced by the presence of metal ions. Force field parameters are nowadays available also for these 'exotic' atoms and several biological systems have been successfully studied.
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Advances in Research on Metalloproteins
2014Metal ions play essential roles in biological processes. Ions such as K(+) and Na(+) are important in ion transport, and Mg(2+), Ca(2+), and Zn(2+) are important chelators in many processes, including phosphotransfer and harvesting of light for energy metabolism.
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