Results 91 to 100 of about 78,711 (297)

Copper Tolerance Mediated by FgAceA and FgCrpA in Fusarium graminearum

Frontiers in Microbiology, 2020
All organisms must secure essential trace elements (e.g., Cu) for survival and reproduction. However, excess trace element accumulation in cells is highly toxic. The maintenance of copper (Cu) homeostasis has been extensively studied in mammals, bacteria,
Xin Liu, Xin Liu, Xin Liu, Yichen Jiang, Yichen Jiang, Dan He, Xin Fang, Xin Fang, Jianhong Xu, Jianhong Xu, Yin-Won Lee, Yin-Won Lee, Nancy P. Keller, Nancy P. Keller, Jianrong Shi, Jianrong Shi   +15 more
doaj   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, Volume 12, Issue 25, July 3, 2025.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Cardiac-Specific Overexpression of Metallothionein Rescues against Cigarette Smoking Exposure-Induced Myocardial Contractile and Mitochondrial Damage

PLoS ONE, 2013
Objectives Second hand cigarette smoke is an independent risk factor for cardiovascular disease. Although a tie between smoking and cardiovascular disease is well established, the underlying mechanisms still remains elusive due to the lack of adequate ...
N. Hu, Xuefeng Han, E. Lane, F. Gao, Yingmei Zhang, Jun Ren   +5 more
semanticscholar   +1 more source

Detection of Metallothionein in Javanese Medaka (Oryzias javanicus), Using a scFv-Immobilized Protein Chip

Sensors, 2018
Environmental pollution by various industrial chemicals and biological agents poses serious risks to human health. Especially, marine contamination by potentially toxic elements (PTEs) has become a global concern in recent years.
Euiyeon Lee, Hyunjin Jeon, Chungwon Kang, Seonock Woo, Seungshic Yum, Youngeun Kwon   +5 more
doaj   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Banerji, Becker, Becker, Buetti, Cartwright, Chandler, Chen, Church, DeFranco, Gilbert, Gluecksohn-Waelsch, Gorman, Granner, Greengard, Hargrove, Hashimoto, Hochschild, Hynes, Karin, Karin, Killary, Maniatis, Maxam, Melton, Miksicek, Payvar, Pelham, Ptashne, Renkawitz, Ringold, Ruiz-Bravo, Scheidereit, Scherer, Schmid, Searle, Serfling, Sergeant, Singh, Slater, Yamamoto, Zaret, Zinn   +41 more
core   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source

Metallothionein immunoexpression in oral leukoplakia [PDF]

, 2008
Objectives: to report the immunoexpression of metallothionein in oral leukoplakia and to correlate with histological grade and clinical localization. Leukoplakia is the most common potentially malignant lesion of the oral cavity.
Aguiar, Maria Cássia Ferreira, Horta, Martinho Campolina Rebello, Johann, Aline Cristina Batista Rodrigues, Mesquita, Ricardo Alves, Silveira Júnior, João Batista, Souto, Giovanna Ribeiro   +5 more
core  

Genetically encoded fluorescent redox probes. [PDF]

, 2013
Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling.
Ai, Hui-Wang, Ren, Wei
core   +3 more sources

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Effects of Altering Freshwater Chemistry on Physiological Responses of Rainbow Trout to Silver Exposure [PDF]

, 1999
The influence of different water Cl- (50–600 μM), Ca2+ (50–1,500 μM), Na+ (50–1,500 μM), or dissolved organic carbon (DOC, 0.31–5 mg/L) levels on silver-induced physiological and biochemical perturbations of rainbow trout were investigated.
Bergman, Bonting, Buccafusco, Campbell, Coleman, Davies, Diamond, Engel, Erickson, Evans, Galvez, Hogstrand, Hogstrand, Hollis, Janes, LeBlanc, Lemke, Morel, Morel FHM., Morgan, Nebeker, Pagenkopf, Perry, Perry, Playle, Playle, Potts, Schecher, Simkiss, Steel, Webb, Wood, Wood, Zall   +33 more
core   +2 more sources