Results 111 to 120 of about 77,240 (295)
Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas.
Carcinogenesis, 2012 Members of the metallothionein (MT) family are short, cysteine-rich proteins involved in metal metabolism and detoxification, suggesting that MT proteins protect cells from damage caused by electrophilic carcinogens and thereby constitute a critical ...
Jun-Zhe Mao +13 more
semanticscholar +1 more source
Neurosignals, 1994 The metal-binding protein, metallothionein (MT) has been found to be primarily produced by astrocytes in the rat and human brain. This review discusses the relationship of glial MT to the distribution of metals in the brain, possible roles of MT in the regulation of glial enzymes and other glial proteins, and the possible role of a subset of MT ...
openaire +2 more sources
Molecular Genetics & Genomic Medicine, 2019 Background Liver cancer is the fifth most common cancer, and hepatocellular carcinoma (HCC) is the major liver tumor type seen in adults. HCC is usually caused by chronic liver disease such as hepatitis B virus or hepatitis C virus infection.
Sufang Wang, Michael Gribskov
doaj +1 more source
Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]
, 2010 The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Gispert, Suzana +5 more
core +2 more sources
Біологічні студії, 2012 Cis-dichlorodiammineplatinum (II), commonly known as cisplatin, is a widely used anticancer drug. However, the therapeutic efficacy of the drug is limited due to various dose-limiting side effects and development of acquired resistance. The resistance of
H. Falfushynska +3 more
doaj +1 more source
Metallothionein Pada Hati Ikan Sebagai Biomarker Pencemaran Kadmium (Cd) Di Perairan Kaligarang Semarang (Metallothionein in the Fish Liver as Biomarker of Cadmium (Cd) Pollution in Kaligarang River Semarang) [PDF]
, 2014 Early markers of cadmium pollution in the river Kaligarang need to know as heavy metal pollution monitoring tool, given the river Kaligarang used to meet the needs of drinking water for the city of Semarang.
Dewi, N. K. (Nur) +2 more
core
Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health [PDF]
, 2004 Cadmium (Cd) was recently identified as a risk factor for osteoporosis. Skeletal damage may be the critical effect of low-level long-term exposure to Cd in the general population exposed via food, but the mechanisms behind this are not clearly understood.
Guérin, Thierry +2 more
core +1 more source
Human hepatic metallothioneins
FEBS Letters, 1974 Metallothioneins are sulfur-rich proteins first recognized in equine and human renal cortex by their unusual content of cadmium [ 1,2] . All preparations contained in addition, however, equally appreciable amounts of zinc and the variations in the relative amounts of the two metals suggested even in the earliest studies that they may replace each other.
Rolf H. O. Bühler, Jeremias H. R. Kägi
openaire +3 more sources
Thiolate ligands in metallothionein confer redox activity on zinc clusters.
Proceedings of the National Academy of Sciences of the United States of America, 1998 We postulate a novel and general mechanism in which the redox-active sulfur donor group of cyst(e)ine confers oxidoreductive characteristics on stable zinc sites in proteins. Thus, the present, an earlier, and accompanying manuscripts [Maret, W., Larsen,
Wolfgang Maret, Bert L. Vallee
semanticscholar +1 more source
The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia [PDF]
, 2014 Background: Frankia are actinobacteria that form a symbiotic nitrogen-fixing association with actinorhizal plants, and play a significant role in actinorhizal plant colonization of metal contaminated areas.
Furnholm, Teal R., Tisa, Louis S.
core +2 more sources