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The zinc balance: competitive zinc metalation of carbonic anhydrase and metallothionein 1A.
Biochemistry, 2014The small, cysteine-rich metallothionein family of proteins is currently considered to play a critical role in the provision of metals to metalloenzymes.
Tyler B. J. Pinter, M. Stillman
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The function of metallothionein
Neurochemistry International, 1995Since its discovery in 1957 metallothionein (MT) has remained a protein in search of a function. After 40 years of frustrating efforts, three areas of research point to its zinc cluster structure as the basis of its functional potential: (1) the regulation of MT gene expression by zinc-dependent transcription factors, (2) neuronal growth inhibition in ...
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2013
The role of cadmium in inducing hepatotoxicity and nephrotoxicity, as well as the role of metallothionein as a cadmium-induced intracellular protector of toxicity has been described.
Breljak, Davorka +3 more
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The role of cadmium in inducing hepatotoxicity and nephrotoxicity, as well as the role of metallothionein as a cadmium-induced intracellular protector of toxicity has been described.
Breljak, Davorka +3 more
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2009
The earliest perception restricted the occurrence of metallothioneins to animals, fungi, and certain bacteria and assigned the corresponding functions in plants to the enzymatically synthesized phytochelatins. This picture has now clearly changed, and the existence of plant metallothioneins is generally accepted. Compared to the vertebrate forms, plant
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The earliest perception restricted the occurrence of metallothioneins to animals, fungi, and certain bacteria and assigned the corresponding functions in plants to the enzymatically synthesized phytochelatins. This picture has now clearly changed, and the existence of plant metallothioneins is generally accepted. Compared to the vertebrate forms, plant
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Metallothionein and brain inflammation
JBIC Journal of Biological Inorganic Chemistry, 2011Since the seminal discoveries of Bert Vallee regarding zinc and metallothioneins (MTs) more than 50 years ago, thousands of studies have been published concerning this fascinating story. One of the most active areas of research is the involvement of these proteins in the inflammatory response in general, and in neuroinflammation in particular.
Manso, Y +4 more
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Molecular splicing of metallothionein — study on domains of metallothionein [PDF]
, 1999 Mammalian metallothioneins (MTs) are a class of low-molecular weight proteins containing 20 cysteine residues out of a total of 61 amino acid residues. MTs fold into two separate domains in the presence of certain metal ions [1,2]. Each domain binds metal ions in a polynuclear metalthiolate cluster with ligation through thiolates of the 20 cysteines ...
Yan-Jiao Zhou +3 more
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Biochemistry, 1994
A new member of the metallothionein (MT) gene family was discovered that lies about 20 kb 5' of the MT-III gene in both mouse and human. The MT-IV proteins are highly conserved in both species and have a glutamate insertion at position 5 relative to the ...
C. Quaife +6 more
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A new member of the metallothionein (MT) gene family was discovered that lies about 20 kb 5' of the MT-III gene in both mouse and human. The MT-IV proteins are highly conserved in both species and have a glutamate insertion at position 5 relative to the ...
C. Quaife +6 more
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Metallothionein and anticancer agents: the role of metallothionein in cancer chemotherapy
Journal of Neuro-Oncology, 1993Metallothioneins (MTs) are intracellular proteins containing the highest amount of thiol groups within the cytoplasm. These thiol groups are able to bind several cytotoxic agents, such as platinum compounds and alkylating agents. Increased levels of MT are one mechanism of resistance to these anticancer drugs, as intracytoplasmic binding of MT prevents
Norbert Roosen +2 more
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Metallothionein in Antarctic Fish
1998Zinc occupies a prominent position among transition and d10 elements because of the role played in many biological processes [1,2], including catalysis [3], transcription and translation [4]. The functional role of zinc depends on the large variety of metallorganic complexes produced by this element as a result of its interaction with different protein
V Carginale +8 more
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