NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
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