Urinary Free Metanephrines for Diagnosis of Pheochromocytoma and Paraganglioma [PDF]
Endocrinology and Metabolism, 2021 Background Pheochromocytoma and paraganglioma (PPGL) is diagnosed through biochemical confirmation of excessive catecholamines in urine and plasma. Recent technological developments have allowed us to measure urinary free metanephrines; however, the ...
Jiyeon Ahn +6 more
doaj +3 more sources
Multiplexed Dilute-and-Shoot Liquid Chromatography–Multiple-Reaction Monitoring Mass Spectrometry Clinical Assay for Metanephrines and Catecholamines in Human Urine [PDF]
MetabolitesBackground: Quantifying urinary catecholamines and metanephrines is essential for the clinical screening and diagnosis of neuroendocrine tumours. HPLC with electrochemical detection (HPLC-ECD) is commonly used for this type of analysis but requires ...
Deema O. Qasrawi +4 more
doaj +2 more sources
Optimized procedures for testing plasma metanephrines in patients on hemodialysis [PDF]
Scientific Reports, 2021 Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3 ...
Christina Pamporaki +16 more
doaj +2 more sources
Stressless sampling to improve diagnostics of catecholamine excess: new assay to determine metanephrines in saliva [PDF]
Endocrine ConnectionsDetermination of metanephrines in saliva has been reported as a pain- and hazard-free alternative to plasma-based tests with a potential to reduce false-positive results during diagnostic work-up for neuroendocrine tumours.
Per M Thorsby +4 more
doaj +2 more sources
A potentially dangerous case of mistaken identity: giant asymptomatic composite phaeochromocytoma [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsSmall clinically silent phaeochromocytoma (PCC) can be identified in modern clinical practice as apparent adrenal incidentaloma or during screening of patients with familial tumour syndromes.
Annabelle G Hayes, Morton G Burt
doaj +2 more sources
Enzyme and acid deconjugation of plasma sulfated metanephrines [PDF]
Clinica Chimica Acta, 2014 Total (i.e. free+sulfated) metanephrines in plasma is a biomarker for the diagnosis of pheochromocytoma/paraganglioma. Sulfated metanephrines must be completely deconjugated by perchloric acid hydrolysis or sulfatase treatment prior to analytical measurement to enable quantification by current techniques.
Glauser, M. +8 more
openaire +5 more sources
Studies on radioimmunoassay of metanephrine.
Chemical and Pharmaceutical Bulletin, 1980 A, Shirahata +3 more
openaire +4 more sources
An uncommon case of pheochromocytoma with positive biochemical workup and absence of tumor [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsPheochromocytomas are rare neuroendocrine tumors derived from adrenal chromaffin cells that result in hyperactivity of the sympathetic nervous system. We present the case of a patient with biochemical evidence of pheochromocytoma, but surgical pathology ...
Nicole Chan +3 more
doaj +2 more sources
Urine-normetanephrine, a predictor of mortality risk in patients with adrenal adenomas [PDF]
Scientific ReportsUrine-metanephrines are used in the screening for pheochromocytomas in patients with adrenal incidentalomas, but their potential as markers for mortality in patients with adrenal adenomas has not been studied. A retrospective cohort study was designed to
Albin Kjellbom +4 more
doaj +2 more sources
Adrenal Ganglioneuroma: A Rare Incidentaloma [PDF]
National Journal of Laboratory Medicine, 2021 Adrenal ganglioneuroma is a very rare tumour of sympathetic nervous system that originate from neural crest sympathogonia which are completely undifferentiated cells of the sympathetic nervous system, constituting 20 to 30% of all Ganglioneuromas (GNs).
Rashmi Rani Bharti +2 more
doaj +1 more source