Results 71 to 80 of about 56,949 (226)

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Clinical Significance of a Cell‐Of‐Origin‐Based Classification in Pancreatic Ductal Adenocarcinoma

Cancer Science, EarlyView.
Schematic overview of a cell‐of‐origin‐based classification of pancreatic ductal adenocarcinoma (PDAC), highlighting distinct biological features and therapeutic implications of Acinar‐ and Ductal‐subtypes. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic options and poor clinical ...
Tatsuya Kikuchi, Soichiro Ako, Hironari Kato, Hideaki Kinugasa, Masaki Uchida, Takashi Oda, Ryosuke Hirai, Akihiro Matsumi, Kazuya Miyamoto, Hiroyuki Terasawa, Yuki Fujii, Daisuke Uchida, Kazuyuki Matsumoto, Koichiro Tsutsumi, Shigeru Horiguchi, Kazuya Yasui, Tomokazu Fuji, Kosei Takagi, Hirokazu Kato, Tomoyuki Honda, Fumio Otsuka, Motoyuki Otsuka   +21 more
wiley   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Bullous Eruption Associated With Loncastuximab Tesirine in a Patient With Diffuse Large B‐Cell Lymphoma

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Loncastuximab tesirine (LT) is an antibody‐drug conjugate (ADC), a novel class of therapeutics that combines a target‐specific monoclonal antibody with a cytotoxic agent via a chemical linker. LT has been approved in the United States as therapy for relapsed or refractory diffuse large B‐cell lymphoma (DLBCL).
Daniella Jaguan, Cuong Nguyen, Jennifer N. Choi   +2 more
wiley   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Clinical and surgical findings in a mare with unilateral ovarian fibroleiomyoma and adhesions

Equine Veterinary Education, EarlyView.
Summary This case report describes the clinical presentation, ultrasonographic findings, surgical management and outcome of a 7‐year‐old Warmblood mare presented for recurrent colic, weight loss and poor performance. Rectal palpation identified a firm mass in the left caudal abdomen, which appeared on ultrasonography as a large, fluid‐filled, cyst‐like
N. Scilimati, P. Berni, E. Blanc, M. Di Pentima, F. Leonardi, S. Napoli, C. Palmieri, M. Ruggeri, R. Gialletti   +8 more
wiley   +1 more source

Integrative single‐cell transcriptomic analysis deciphers heterogeneous characteristics of gastrointestinal tract cancer

Clinical and Translational Medicine
Background Gastrointestinal tract cancer (GIC), including oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC), is characterised with high global incidence and mortality rates, with similar tumourigenic processes.
Chuwen Sun, Tong Li, Xin Jin, Zhihui Xiu, Hang Su, Huanming Yang, Ming Liu, Kui Wu   +7 more
doaj   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

Endocervical gastric‐type AIS: a rare histologic finding that further supports the hypothesis of a pyloric‐type metaplastic origin

Histopathology, EarlyView.
Background Gastric‐type adenocarcinoma in situ (gAIS) is a rare, HPV‐independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. Aims To report a case of gAIS and its association with pyloric‐type gastric metaplasia. Materials and Methods A case of gAIS in a 70‐year‐old woman with atypical glandular cells (Pap test) and ...
Michele Paudice, Veronica Parrella, Giulia Scaglione   +2 more
wiley   +1 more source

METAPLASIA OSEA ENDOMETRIAL: CON SOSPECHA DIAGNOSTICA ECOGRAFICA O HISTEROSCOPICA

Revista Chilena de Obstetricia y Ginecología, 2002
Se presentan ocho casos de pacientes en las cuales se sospecha el dignóstico de metaplasia ósea endometrial. Cuatro de ellas son pacientes asintomáticas en las que se realizó la sospecha de metaplasia ósea por medio de una ecografía transvaginal ...
Jaime Corvalán A, Pablo Sanhueza R
doaj