Results 71 to 80 of about 55,042 (230)
Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley +1 more source
Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer
The FEBS Journal, EarlyView.Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa +2 more
wiley +1 more source
An unusual cause of abdominal pain in a male patient: Endometriosis
Avicenna Journal of Medicine, 2014 A rare case of abdominal pain secondary to endometriosis in a 52-year-old man with cirrhosis is presented. The patient had a repair of recurrent inguinal hernia 7 months prior to presentation.
Fadi I Jabr, Venk Mani
doaj +1 more source
Histopathology, EarlyView.Background Gastric‐type adenocarcinoma in situ (gAIS) is a rare, HPV‐independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. Aims To report a case of gAIS and its association with pyloric‐type gastric metaplasia. Materials and Methods A case of gAIS in a 70‐year‐old woman with atypical glandular cells (Pap test) and ...
Michele Paudice +2 more
wiley +1 more source
Histopathology, EarlyView.The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty +7 more
wiley +1 more source
Hippo pathway disruption and YAP1 activation in anogenital papillary squamous intraepithelial lesion
Histopathology, EarlyView.Disruption of the Hippo Pathway with YAP1 activation is a consistent finding in papillary squamous intraepithelial lesions and may underlie their altered epithelial maturation and HPV E6/E7 expression patterns, providing new insight into the pathogenesis of this distinct low‐risk HPV‐associated lesion.
Gloria Zhang +4 more
wiley +1 more source
When to consider an inborn error of immunity: clues for physicians
Internal Medicine Journal, EarlyView.Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Background Although Helicobacter pylori plays a central role in gastric cancer (GC), other microorganisms involved in gastric dysbiosis may also impact carcinogenesis. We aimed to characterize gastric dysbiosis and its role in the transition from non‐atrophic gastritis (NAG) to gastric premalignant lesions (GPLs) in two populations from Nariño,
Juan Camilo Caguazango +6 more
wiley +1 more source
Oral Diseases, EarlyView.ABSTRACT Background Pleomorphic adenoma (PA) is the most common salivary gland tumor, and a subset may recur as recurrent PA (RPA) or progress to carcinoma ex pleomorphic adenoma (CXPA). However, comparative evaluations of their biological behavior and prognostic factors remain limited.
Talita de Carvalho Kimura +7 more
wiley +1 more source