Results 81 to 90 of about 137,582 (366)

Microscopic changes in the spleen due to feline infectious peritonitis

open access: yesUkrainian Journal of Veterinary Sciences, 2022
The relevance of the study is that pathological and morphological changes with feline infectious peritonitis have been studied by few authors and are not fully described.
Viktoriia Lisova, Eduard Kotliarov
doaj   +1 more source

Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]

open access: yes, 2013
Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D   +6 more
core   +2 more sources

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

open access: yesAdvanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu   +10 more
wiley   +1 more source

Metaplasia in the Stomach—Precursor of Gastric Cancer?

open access: yesInternational Journal of Molecular Sciences, 2017
Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide.
Hiroto Kinoshita, Y. Hayakawa, K. Koike
semanticscholar   +1 more source

Combined histological and DNA methylome profiling approaches may provide insights into the pathophysiology of ovarian endometriomas

open access: yesReproductive Medicine and Biology, 2023
Purpose To test the theory that invaginated ovarian surface epithelium and endometrial implants on the ovary form ovarian endometriomas. Methods Adhesion sites of ovarian endometrioma on the peritoneum and consecutive ovarian endometrioma cyst wall ...
Ryo Maekawa   +15 more
doaj   +1 more source

Plasticity of differentiated cells in wound repair and tumorigenesis, Part II: Skin and intestine [PDF]

open access: yes, 2018
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas.
Burclaff, Joseph, Mills, Jason C
core   +2 more sources

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

open access: yesAdvanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye   +11 more
wiley   +1 more source

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

open access: yesAdvanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang   +14 more
wiley   +1 more source

Short segment Barrett's esophagus and distal gastric intestinal metaplasia Esôfago de Barrett de segmento curto e metaplasia intestinal gástrica distal

open access: yesArquivos de Gastroenterologia, 2006
BACKGROUND: Short segment Barrett's esophagus is defined by the presence of
Judite Dietz   +5 more
doaj   +1 more source

Risk factors in gastric cancer [PDF]

open access: yes, 2010
STATE OF THE ART: Gastric cancer (GC) is still a major health problem worldwide due to its frequency, poor prognosis and limited treatment options. At present prevention is likely to be the most effective means of reducing the incidence and mortality ...
COMPARE, DEBORA   +2 more
core  

Home - About - Disclaimer - Privacy