Results 11 to 20 of about 1,018,202 (279)

Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial

Nature Medicine, 2022
Trastuzumab deruxtecan is an antibody–drug conjugate with high extracranial activity in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. We conducted the prospective, open-label, single-arm, phase 2 TUXEDO-1 trial.
R. Bartsch, A. Berghoff, J. Furtner, M. Marhold, E. Bergen, S. Roider-Schur, A. Starzer, H. Forstner, B. Rottenmanner, K. Dieckmann, Z. Bagó-Horváth, H. Haslacher, G. Widhalm, A. Ilhan-Mutlu, C. Minichsdorfer, T. Fuereder, T. Szekeres, L. Oehler, B. Gruenberger, C. Singer, A. Weltermann, R. Puhr, M. Preusser   +22 more
semanticscholar   +1 more source

Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline.

Practical Radiation Oncology, 2022
PURPOSE This guideline provides updated evidence-based recommendations addressing recent developments in the management of patients with brain metastases, including advanced radiation therapy techniques such as stereotactic radiosurgery (SRS) and ...
V. Gondi, Glenn Bauman, Lisa Bradfield, S. Burri, Alvin R. Cabrera, D. Cunningham, B. Eaton, J. Hattangadi-Gluth, Michelle M Kim, R. Kotecha, Lianne Kraemer, Jing Li, Seema Nagpal, C. Rusthoven, J. H. Suh, W. A. Tomé, T. J. Wang, A. Zimmer, Mateo Ziu, Paul D. Brown   +19 more
semanticscholar   +1 more source

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.

Journal of Clinical Oncology, 2021
PURPOSE To provide guidance to clinicians regarding therapy for patients with brain metastases from solid tumors. METHODS ASCO convened an Expert Panel and conducted a systematic review of the literature.
M. Vogelbaum, P. Brown, H. Messersmith, P. Brastianos, S. Burri, D. Cahill, I. Dunn, L. Gaspar, N. T. Gatson, V. Gondi, J. Jordan, A. Lassman, Julia Maués, N. Mohile, Navid Redjal, G. Stevens, E. Sulman, M. J. van den Bent, H. Wallace, J. Weinberg, G. Zadeh, D. Schiff   +21 more
semanticscholar   +1 more source

IMpower150 Final Exploratory Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in Key NSCLC Patient Subgroups With EGFR Mutations or Metastases in the Liver or Brain.

Journal of Thoracic Oncology, 2021
INTRODUCTION Final overall survival (OS) analyses are presented for EGFR mutations and liver or brain metastases subgroups in the phase III IMpower150 study (NCT02366143) evaluating atezolizumab+bevacizumab+carboplatin/paclitaxel (ABCP) or atezolizumab ...
N. Nogami, F. Barlesi, M. Socinski, M. Reck, C. Thomas, F. Cappuzzo, T. Mok, G. Finley, J. Aerts, F. Orlandi, D. Moro-Sibilot, R. Jotte, D. Stroyakovskiy, L. Villaruz, D. Rodríguez-Abreu, D. Lim, D. Merritt, S. Coleman, Anthony Lee, G. Shankar, Wei Yu, I. Bāra, M. Nishio   +22 more
semanticscholar   +1 more source

Epidemiology of Brain Metastases and Leptomeningeal Disease.

Neuro-Oncology, 2021
Brain metastases affect a significant percentage of patients with advanced extracranial malignancies. Yet, the incidence of brain metastases remains poorly described, largely due to limitations of population-based registries, a lack of mandated reporting
N. Lamba, P. Wen, A. Aizer
semanticscholar   +1 more source

Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review

Journal of Bone Oncology, 2022
Highlights • The clinical incidence of spinal metastases is 15.67%, two thirds are metastases from breast-, prostate- or lung cancer.• 9.6% of patients with spinal metastases develop metastatic epidural spinal cord compression.• 1 out of 8 (12.6%) of ...
Ruben van den Brande, Erwin MJ Cornips, M. Peeters, P. Ost, C. Billiet, Erik Van de Kelft   +5 more
semanticscholar   +1 more source

Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial

The Lancet, 2016
Summary Background Whole brain radiotherapy (WBRT) and dexamethasone are widely used to treat brain metastases from non-small cell lung cancer (NSCLC), although there have been no randomised clinical trials showing that WBRT improves either quality of ...
P. Mulvenna, M. Nankivell, R. Barton, C. Faivre-Finn, Paula Wilson, Elaine McColl, B. Moore, I. Brisbane, D. Ardron, T. Holt, Sally Morgan, Caroline Lee, K. Waite, N. Bayman, Cheryl A Pugh, Benjamin Sydes, Richard Stephens, Mahesh K. B. Parmar, R. Langley   +18 more
semanticscholar   +1 more source

Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.

Journal of Clinical Oncology, 2020
PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials for fear that poor survival could mask the benefit of otherwise promising treatments.
P. Sperduto, S. Mesko, Jing Li, D. Cagney, A. Aizer, N. Lin, E. Nesbit, T. Kruser, J. Chan, S. Braunstein, Jessica Lee, J. Kirkpatrick, W. Breen, P. Brown, D. Shi, H. Shih, H. Soliman, A. Sahgal, R. Shanley, W. Sperduto, E. Lou, A. Everett, D. Boggs, L. Masucci, D. Roberge, J. Remick, K. Plichta, J. Buatti, Supriya K. Jain, L. Gaspar, Cheng-Chia Wu, T. Wang, J. Bryant, M. Chuong, Y. An, V. Chiang, Toshimichi Nakano, H. Aoyama, M. Mehta   +38 more
semanticscholar   +1 more source

Characteristics and treatments of large cystic brain metastasis: radiosurgery and stereotactic aspiration. [PDF]

, 2015
Brain metastasis represents one of the most common causes of intracranial tumors in adults, and the incidence of brain metastasis continues to rise due to the increasing survival of cancer patients. Yet, the development of cystic brain metastasis remains
Cheok, Stephanie, Chung, Lawrance K, Kim, Chang Jin, Kim, Jeong Hoon, Kim, Moinay, Kwon, Do Hoon, Lee, Percy, Tenn, Stephen, Thill, Kimberly, Ung, Nolan, Voth, Brittany, Yang, Isaac   +11 more
core   +1 more source

Total-liver-volume perfusion CT using 3-D image fusion to improve detection and characterization of liver metastases [PDF]

, 2008
The purpose of this study was to evaluate the feasibility of a totalliver- volume perfusion CT (CTP) technique for the detection and characterization of livermetastases.
Kuijk, Cornelis van, Meijer, Sybren, Meijerink, Martijn, Tol, Petrousjka van den, Waesberghe, Jan van, Weide, Lineke van der   +5 more
core   +3 more sources