Results 141 to 150 of about 2,015,361 (384)

Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009–2014) [PDF]

, 2015
Damiano Stefanello, Paolo Buracco, Silvia Sabattini, Riccardo Finotello, Chiara Giudice, Valeria Grieco, Selina Iussich, Massimiliano Tursi, T. Scase, Stefano Di Palma, Giuliano Bettini, Roberta Ferrari, Marina Martano, Francesca Gattino, Mary Marrington, M. Mazzola, Maria Elisabetta Vasconi, Maurizio Annoni, Laura Marconato   +18 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4+T cell cytotoxicity through ESM1

npj Precision Oncology
Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer adaptive immune suppressive response.
Jiatao Li, Juan Feng, Ziyong Li, Yuanli Ni, Limei Liu, Xia Lei, Zixuan Chai, Na Zhuang, Jiake Xu, Yongpeng He, Juanjuan Shan, Cheng Qian   +11 more
doaj   +1 more source

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program

EMBO Molecular Medicine, 2018
Epithelial‐to‐mesenchymal transition (EMT) is a recognized eukaryotic cell differentiation program that is also observed in association with invasive tumors.
Yang Chen, Valerie S LeBleu, Julienne L Carstens, Hikaru Sugimoto, Xiaofeng Zheng, Shruti Malasi, Dieter Saur, Raghu Kalluri   +7 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

Beilstein Journal of Nanotechnology, 2019
Diosgenin (Di), a steroidal sapogenin derived from plants, has been shown to exert anticancer effects in preclinical studies. Using Di as a starting material, various Di derivatives were designed and synthesized, aiming to discover new steroid-based ...
Liang Xu, Dekang Xu, Ziying Li, Yu Gao, Haijun Chen   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma. [PDF]

, 2019
Meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare tumor with propensity for recurrence and metastasis. Although multiple classification schemes have been proposed, optimal risk stratification remains unclear, and the prognostic ...
Alexander, Brian M, Brastianos, Priscilla K, Brat, Daniel, Brown, Paul D, Caron, Alissa, Ferrarese, Fabio, Fritchie, Karen, Giannini, Caterina, Guajardo, Andrew, Haller, Florian, Jenkins, Sarah, Jensch, Kassandra, Kaplan, Alexander, Link, Michael, Louis, David N, Moskalev, Evgeny A, Perry, Arie, Raleigh, David R, Rodriguez, Fausto J, Rossi, Sabrina, Santagata, Sandro, Velázquez Vega, José E, Wu, Ashley   +22 more
core  

Using Endobronchial Ultrasound Features to Predict Lymph Node Metastasis in Patients With Lung Cancer [PDF]

, 2011
Jessica S. Wang Memoli, Ezzat El-Bayoumi, Nicholas J. Pastis, Nichole T. Tanner, Mario Gómez, John T. Huggins, Georgiana Onicescu, Elizabeth Garrett‐Mayer, Kent Armeson, Katherine K. Taylor, Gerard A. Silvestri   +10 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source