Results 161 to 170 of about 1,959,855 (381)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Combination of indocyanine green with medical adhesive for preoperative pulmonary nodule localization

World Journal of Surgical Oncology
Background Preoperative localization of pulmonary nodules is crucial for sublobar resection under thoracoscopy; however, controversy persists over the optimal localization method in terms of accuracy and safety.
Yulong Tan, Wenhao Wang, Xuan Wang, Baosen Wen, Haoxin Liu, Yifeng Qian, Quandong Zhu, Xiaofeng Chen, Huijun Zhang   +8 more
doaj   +1 more source

Targeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer
Background Immune escape is an important feature of hepatocellular carcinoma (HCC). The overall response rate of immune checkpoint inhibitors (ICIs) in HCC is still limited.
Sunzhe Xie, Hao Wang, Xin Zheng, Lu Lu, Yiran Chen, Lunxiu Qin, Luyu Yang, Xiaotian Shen, Junjie Pan, Jixuan Chen, Jiaqi Meng, Zhenchao Chen, Yitong Li, Bolun Zhu, Wenwei Zhu   +14 more
doaj   +1 more source

Bone Destruction in Carcinoma of the Uterine Cervix, by Direct Propagation or by Lymphogenic or Hematogenic Metastasis [PDF]

, 1940
Flemming Nørgaard
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The metabolism of cancer cells during metastasis

Nature Reviews. Cancer, 2021
G. Bergers, S. Fendt
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

CASE OF MUMPS, WITH ENDOCARDIAL MURMURS, HIGH TEMPERATURE AND METASTASIS TO TESTES. [PDF]

, 1882
John Appleyard
openalex   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

UNUSUAL METASTASIS IN MUMPS, With Report of Three Fatal Cases. [PDF]

, 1887
F. D. HALDEMAN
openalex   +1 more source