Results 81 to 90 of about 134,430 (328)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Prognostic significance of serine-phosphorylated STAT3 expression in pT1-T2 oral tongue carcinoma [PDF]

, 2015
Objectives. Phosphorylated (activated) STAT3 (pSTAT3) is a regulator of numerous genes that play an essential part in the onset, development and progression of cancer; it is involved in cell proliferation and preventing apoptosis, and in invasion ...
Cappellesso, R, DE FILIPPIS, Cosimo, Fasanaro, E, Giacomelli, L, Marino, F, Marioni, Gino, Ottaviano, Giancarlo, Staffieri, Alberto, Staffieri, C, Stellini, Edoardo, Val, M   +10 more
core   +3 more sources

A case of basal cell carcinoma of skin with bone metastasis: a case report

Journal of Medical Case Reports
Background Basal cell carcinoma is the most prevalent skin cancer, most characterized by local aggressiveness but with low metastatic potential, and bone metastasis is quite heterogeneous, thus the incidence profile is variable size from 0.0028% to 0.5%.
Azadeh Khayyat, MohammadAli Esmaeil Pour, Hamid Nasrollahi, Mohammad Mehdi Mehrabi, Seyed Amir Zohouri, Bita Geramizadeh   +5 more
doaj   +1 more source

Basosquamous Carcinoma Arising from the Vulva: A Case Report

Case Reports in Oncology
Introduction: Basosquamous carcinoma (BSC) of the vulva is an uncommon tumor that primarily consists of basal cell carcinoma with squamous differentiation.
Fatma Saadallah, Ayoub Ghazouani, Ines Zemni, Haykel Turki, Houyem Mansouri, Ghada Sahraoui, Tarek Ben Dhiab   +6 more
doaj   +1 more source

Two Basal Cell Carcinomas of the Axillae: A Metastasis or an Independent Development?

Case Reports in Dermatological Medicine, 2015
Cutaneous basal cell carcinoma (BCC) is a common malignancy amongst the elderly. BCC rarely metastasises, and fewer than 300 cases of metastatic BCC have been reported in the literature.
Yuichiro Endo, Yoshiki Miyachi
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Adrenal insufficiency due to bilateral adrenal metastases - A systematic review and meta-analysis [PDF]

, 2019
Objective: Bilateral adrenal metastases may cause adrenal insufficiency (AI) but it is unclear if screening for AI in patients with bilateral adrenal metastases is justified, despite the potential for adrenal crises. Method: A search using PubMed/Medline,
Falhammar, Henrik, Rushworth, R Louise, Tallis, Philippa H, Torpy, David J   +3 more
core   +1 more source

Dermatological Malignancies at a University Teaching Hospital in north-western Tanzania: A Retrospective Review of 154 Cases [PDF]

, 2012
Dermatological malignancies are among the most common form of cancers and the global incidence has been increasing at an alarming rate. A retrospective study was conducted to determine the prevalence, histopathological pattern, anatomical distribution ...
Chalya, Phillipo L., Gilyoma, Japhet M., Kahima, Kahima J., Kanumba, Emmanuel S., Masalu, Nestory, Mawala, Brian, Rambau, Peter   +6 more
core   +2 more sources

Resistance to anti-PD-1-based immunotherapy in basal cell carcinoma: a case report and review of the literature

Journal for ImmunoTherapy of Cancer, 2018
Background Immunotherapy with immune checkpoint inhibitors has radically changed the management of a broad spectrum of tumors. In contrast, only very limited information is available about the efficacy of these therapies in non-melanoma skin cancers ...
Francesco Sabbatino, Antonio Marra, Luigi Liguori, Giosuè Scognamiglio, Celeste Fusciello, Gerardo Botti, Soldano Ferrone, Stefano Pepe   +7 more
doaj   +1 more source