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Gemcitabine in metastatic breast cancer
Expert Review of Anticancer Therapy, 2005Gemcitabine is a pyrimidine antimetabolite which has shown activity in metastatic breast cancer both as a single agent, but also in various combination regimens. It is characterized by a unique mechanism of action which includes cytotoxic self-potentiation, masked DNA chain termination and potent inhibition of DNA repair.
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Metastatic view of breast cancer
Cancer and Metastasis Reviews, 2012The ancient view regarding breast cancer as a metastasis has not been supported so far by experimental evidence. We have implanted nephroblastoma tumor cells resulting in a rat metastatic kidney capsule-parathymic lymph node (PTN) model. India ink implantation confirmed the lymphatic connection between the primary tumor of the kidney and PTNs.
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Treatment of metastatic breast cancer
Seminars in Oncology Nursing, 1991Relapse of breast cancer connotes a dire prognosis. However, long-term survival with remissions and disease exacerbation are possible using conservative treatment strategies and often sequential hormonal manipulations. Hormonal therapy is the mainstay of metastatic breast cancer treatment for patients with hormonally sensitive tumors; cytotoxic ...
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Treatment of Metastatic Breast Cancer
Journal of the National Comprehensive Cancer Network, 2014Many newer agents in combination are being studied in the front-line treatment of women with HER2-positive metastatic breast cancer (MBC), but the story in the endocrine arena is more about the wise use of new strategies to overcome endocrine resistance, because no new antihormonal agents have been approved in the past decade.
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Breast surgery for metastatic breast cancer
British Journal of Community Nursing, 2018Deborah Kirk Walker, Lisa Whitehead
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