Results 191 to 200 of about 302,269 (383)

Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products

open access: yesChemistry &Biodiversity, EarlyView.
Endophytic fungi of P. auritum were evaluated for their ability to produce inhibitors of formation of advanced glycation end products (AGEs). Neopestalotiopsis sp. H2 and Diaporthe sp. H5 extracts were the most active. So, we performed their chemical profiling by untargeted and phenolics‐targeted metabolomic approaches to identify the potential ...
Lory Sthephany Rochín‐Hernández   +3 more
wiley   +1 more source

Benefits of Metformin in Attenuating the Hallmarks of Aging.

open access: yesCell Metabolism, 2020
Ameya Sadguru Kulkarni   +2 more
semanticscholar   +1 more source

Transcatheter Aortic Valve Implantation in a Ross Procedure Patient With Severe Autograft Regurgitation: A Case Report

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Surgical aortic valve replacement (AVR) is the standard treatment for symptomatic severe neo‐aortic regurgitation in Ross patients. The only previous report of a transcatheter aortic valve implantation (TAVI) in a Ross patient required valve‐in‐valve rescue. Thus, this is the first uncomplicated TAVI procedure in a Ross patient.
Anindya Mukherjee   +3 more
wiley   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano   +8 more
wiley   +1 more source

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

open access: yesNew England Journal of Medicine, 2006
S. Kahn   +10 more
semanticscholar   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe   +4 more
wiley   +1 more source

Effect of Energy Metabolism on NF-kB activity in Ovarian Cancer [PDF]

open access: yes, 2018
NF-kB is a transcription factor involved in cancer cell growth and survival. The activation of NF-kB can be assessed by monitoring phosphorylation of RelA p65 at Ser-536, which is a surrogate of the NF-kB transcription factor activation. The objective of
Bagri, Simren K
core   +1 more source

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