Results 201 to 210 of about 297,887 (387)
Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]
, 2019 Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core
ESC Heart Failure, EarlyView.Abstract Sodium‐glucose cotransporter‐2 (SGLT2) inhibitors represent one of the main cornerstones of heart failure treatment. Nevertheless, while the cardiovascular beneficial effects of these drugs have been clearly demonstrated by several clinical trials, in clinical practice, it remains challenging to identify the appropriate timing to start SGLT2 ...
Ruggero Mazzotta +10 more
wiley +1 more source
ESC Heart Failure, EarlyView.Our study examined the real‐world implementation of guideline‐directed medical therapy (GDMT) and its association with mortality and hospitalization in 46 816 patients with heart failure with reduced ejection fraction (HFrEF) from the Danish Heart Failure Registry (2008–2022).
Inge Schjødt +5 more
wiley +1 more source
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Cell Metabolism, 2020 Ameya Sadguru Kulkarni +2 more
semanticscholar +1 more source
Current and novel biomarkers in cardiogenic shock
European Journal of Heart Failure, EarlyView.A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end‐organ dysfunction.
Victor Galusko +5 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.Summary of the study design and key findings. The (+) and (−) signs mean that the variable has a positive or a negative association with growth differentiation factor‐15 (GDF‐15) levels in the fully adjusted model (age, gender, current smoker, body mass index, total cholesterol, systolic blood pressure and N‐terminal pro‐B‐type natriuretic peptide ...
Luca Monzo +11 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard +29 more
wiley +1 more source
World Journal of Biology Pharmacy and Health SciencesMetformin is a widely prescribed medication for managing type 2 diabetes mellitus, a chronic condition characterized by high blood sugar levels. It belongs to the biguanide class of drugs and is often considered a first-line treatment due to its effectiveness, safety profile, and relatively low cost.The primary mechanism of metformin involves reducing ...
Dipali Subhash Bolde +2 more
openaire +2 more sources
European Journal of Heart Failure, EarlyView.Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso +20 more
wiley +1 more source
Bonding of Hydrogel to Biometal Surfaces: Principles, Methods and Applications
Exploration, EarlyView.This article reviews the research progress of hydrogel coatings on biometal surfaces, focusing on biometal surface pretreatment methods, hydrogel‐biometal bonding methods, and applications of hydrogel coatings on biometal surfaces. The article also discusses potential future applications of hydrogel coatings on biometal surfaces to provide a broader ...
Yujie Zhou +10 more
wiley +1 more source