Results 201 to 210 of about 302,269 (383)

Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin [PDF]

, 2000
Paul R. Pryor, Simon C. H. Liu, A E Clark, Jing Yang, Geoffrey D. Holman, David Tosh   +5 more
openalex   +1 more source

Spotlight commentary: Using real‐world data for real‐world evidence generation to advance drug repurposing

British Journal of Clinical Pharmacology, EarlyView.
George S. Q. Tan, Jenni Ilomäki
wiley   +1 more source

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source

Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.

, 1983
Masawo Kakemi, Hideki Sasaki, KAZUE SAEKI, Makiko ENDOH, Kazunori Katayama, TAMOTSU KOIZUMI   +5 more
openalex   +2 more sources

Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real‐World Databases from Korea and Taiwan

Clinical Pharmacology &Therapeutics, EarlyView.
With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko, Philip C. M. Au, Michael Chun‐Yuan Cheng, Ching‐Lung Cheung, Ahhyung Choi, Miyuki Hsing‐Chun Hsieh, Han Eol Jeong, Edward Chia‐Cheng Lai, Brian Meng‐Hsun Li, Kenneth K. C. Man, Jeremy A. Rassen, Daniel Hsiang‐Te Tsai, Shirley V. Wang, Ian C. K. Wong, Ju‐Young Shin, Sohee Park   +15 more
wiley   +1 more source

Beyond the Diagnostic Checklist: A Large‐Scale Analysis of Under‐Recognized Weight Loss Behaviors in Individuals With Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study aimed to explore the diverse range of weight loss behaviors that extend beyond traditional diagnostic criteria, highlighting the variability in symptom presentation. Method We text mined free‐text responses from 1675 participants with anorexia nervosa, bulimia nervosa, or binge‐eating disorder in the Genetic Links to ...
Saakshi Kakar, Una Foye, Helena L. Davies, Elisavet Palaiologou, Chelsea M. Malouf, Laura Meldrum, Iona Smith, Gursharan Kalsi, Karina L. Allen, Gerome Breen, Moritz Herle, Christopher Hübel   +11 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Mechanism by which metformin reduces glucose production in type 2 diabetes. [PDF]

, 2000
Ripudaman S. Hundal, Martin Krššák, Sylvie Dufour, Didier Laurent, Vincent Lebon, Visvanathan Chandramouli, Silvio E. Inzucchi, William C. Schumann, Kitt Falk Petersen, B R Landau, Gerald I. Shulman   +10 more
openalex   +1 more source

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

Effect of Long-Term Treatment with Metformin Added to Hypocaloric Diet on Body Composition, Fat Distribution, and Androgen and Insulin Levels in Abdominally Obese Women with and without the Polycystic Ovary Syndrome [PDF]

, 2000
Renato Pasquali, Alessandra Gambineri, Domenico Biscotti, Valentina Vicennati, L Gagliardi, Donatella Colitta, Stefania Fiorini, Graçiela Estela Cognigni, Marco Filicori, Antonio Maria Morselli‐Labate   +9 more
openalex   +1 more source