Results 161 to 170 of about 13,870 (205)
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Metformin hydrochloride: An antihyperglycemic agent
American Journal of Health-System Pharmacy, 1997The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, and dosage and administration of metformin hydrochloride are reviewed. Metformin is an antihyperglycemic agent; it lowers the blood glucose concentration without causing hypoglycemia.
T B, Klepser, M W, Kelly
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Structure of metformin hydrochloride
Acta Crystallographica Section C Crystal Structure Communications, 1989N,N-Dimethylbiguanide hydrochloride, C 4 H 12 N 5 .Cl, M r =165.6, monoclinic, P2 1 /a, a=7.991(3), b=13.950(5), c=8.020(2)A, β=114.98(3)°, V=810.4(5)A 3 , Z=4, D m =1.35(1), D x =1.357Mgm -3 , MoKα, λ=0.7107A, μ=0.41mm -1 , T=295K, F(000)=352.0, R=0.038 and wR=0.032 for 980 observed reflections with I>3σ(I).
M. Hariharan, S. S. Rajan, R. Srinivasan
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Extended-Release Metformin Hydrochloride
Treatments in Endocrinology, 2004In the new oral, once-daily, extended-release (ER), single-composition osmotic tablet formulation of the biguanide metformin hydrochloride (metformin XT), metformin is released at a controlled rate from a central osmotic tablet core through a semipermeable coating.
Antona J, Wagstaff, David P, Figgitt
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Development of novel mucoadhesive pellets of metformin hydrochloride
Archives of Pharmacal Research, 2009Mucoadhesive polymer-coated pellets containing metformin hydrochloride were prepared by the powder-layering technique using a centrifugal fluidizing (CF)-granulator. Four high-viscosity polymers were applied to make the pellets: 1) hydroxymethylcellulose (HPMC), 2) sodium alginate (Na-Alg), 3) HPMC/Carbopol, and 4) sodium carboxylmethylcellulose (Na ...
Jingshu, Piao +8 more
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Compactibility improvement of metformin hydrochloride by crystallization technique
Advanced Powder Technology, 2012Abstract The objectives of the present study were to address the issues of poor flow and inadequate compressibility of metformin HCl by adopting particle engineering technique. Metformin HCl was crystallized in the presence of polyvinylpyrrolidone (PVP K30). A 3 2 full factorial design (FFD) was employed for optimization of the processing parameters.
Bhavesh S. Barot +4 more
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Pharmaceutical equivalent dissertation of Metformin hydrochloride brands.
Pakistan journal of pharmaceutical sciences, 2019The aim of study is to establish pharmaceutical equivalence of different brands of Metformin tablets available in Karachi, Pakistan. The quality control parameters which are studied are weight variation test, hardness test, thickness, friability, disintegration and dissolution specified by BP/USP (British and United State Pharmacopoeia).
Safila, Naveed +5 more
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[HPLC determination of metformin hydrochloride-related substances].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2006To develop a HPLC assay for the determination of metformin hydrochloride-related substances.The separation was performed on SHIMADZU VP-ODS (250 4.6 mm, 5 microm) column. The mobile phase of dicyandiamide was composed of methyl alcohol-1 mmol x L(-1) sodium dodecylsulfate in 10 mmol x L(-1) phosphate salt solution (60:40) (pH=5.5).
Lin-run, Wang +2 more
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