Results 51 to 60 of about 3,048,178 (294)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Methylene blue decomposition in visible light by CaTiO3/g-C3N4 nanorods produced by the methanol mixing method

Energy Reports, 2023
In recent years, research on using photocatalysts for solar energy has attracted much attention. In this study, g-C3N4 nanorods and CaTiO3 nanocuboids were mixed with methanol to produce g-C3N4 nanorods by molten salt synthesis; CaTiO3 nanocuboids were ...
Hiroki Shimamura, Trang Nakamoto, Kozo Taguchi   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Modulating the electronic state of Cu over Cu/ZnO/SBA-15 catalysts for boosting methanol synthesis from CO2

Green Carbon
Methanol synthesis via CO2 conversion is a “green carbon” route for mitigating the greenhouse effect and recycling carbon resources. However, despite the widespread use of copper-based systems for methanol synthesis in recent decades, the chemical state ...
Kun Jiang, Yunzhao Xu, Fenghai Cao, Baozhen Li, Xiaoyang Xu, Weihao Wang, Yu Tang, Lizhi Wu, Li Tan   +8 more
doaj   +1 more source

Simulation of single-step dimethyl ether synthesis from syngas

Energy Reports, 2020
Dimethyl ether (DME) is an alternative energy that simplest ether. DME has 2 ways to synthesis from syngas. The single-step DME synthesis combined methanol synthesis and methanol dehydration in one reactor.
Chanida Polsen, Phavanee Narataruksa, Piyapong Hunpinyo, Chaiwat Prapainainar   +3 more
doaj   +1 more source

The Role of Carbonate Formation during CO₂ Hydrogenation over MgO-Supported Catalysts: A Review on Methane and Methanol Synthesis

Energies, 2023
Methane and methanol are promising products for CO2 hydrogenation for carbon capture and utilization concepts. In the search for effective, robust, easy-to-manufacture and stable catalysts, supported metal-based catalysts have proven advantageous ...
Kamonrat Suksumrit, Sascha Kleiber, Susanne Lux   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Modeling methanol production via autothermal conversion

Известия Томского политехнического университета: Инжиниринг георесурсов
Relevance. One of the major challenges for any gas field located in permafrost conditions is the formation of hydrate plugs within field pipelines. The procurement and delivery of the required amount of hydrate inhibitor to the gas site can result in ...
Alexander D. Chemezov, Alexander Ya. Gilmanov, Alexander P. Shevelev   +2 more
doaj   +1 more source

On Application of Computer Simulation Technology in Methanol Synthesis in the Coal Chemical Industry

Chemical Engineering Transactions, 2017
In this paper, we build a one-dimensional pseudo-homogenous mathematical model for the interpolate heat- exchange synthesis reactor in the methanol synthesis process in the coal chemical industry and embed Aspen Plus to conduct computer process ...
Qiangqiang An
doaj   +1 more source

Techno-Economic Evaluation of Novel Hybrid Biomass and Electricity-Based Ethanol Fuel Production

Frontiers in Energy Research, 2022
In order to limit climate change, fast greenhouse gas reductions are required already before 2030. Ethanol commonly produced by fermentation of sugars derived either from starch-based raw material such as corn, or lignocellulosic biomass is an ...
Kristian Melin, Harri Nieminen, Daniel Klüh, Arto Laari, Tuomas Koiranen, Matthias Gaderer   +5 more
doaj   +1 more source