Results 71 to 80 of about 3,048,178 (294)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Infrared study of hydrogen bonding of methanol in the liquid phase [PDF]
, 1991 The V(_s)(OH) band of methanol in binary system has been studied by using infrared spectroscopy, over the whole concentration range between 0.01 - 0.7 methanol mole fraction. The aim of this study is to analyze this band which is very complicated, due to
Farwaneh, Sahab Sadi
core
Optimasi Biaya dalam Proses Pemurnian Metanol untuk Mengurangi Resin sebagai Limbah Bahan Berbahaya dan Beracun di PT Kaltim Methanol Industri [PDF]
, 2020 Purification process of raw methanol from its impurities to produce pure methanol at PT. Kaltim Methanol Industri (PT KMI) is carried out by several steps, including degassing, distillation, and adsorption.
Yuliansyah, Ahmad Tawfiequrahman +6 more
core +1 more source
Journal of CO2 UtilizationThis study evaluates Cu/ZnO/Al2O3 catalysts promoted with K2O, BaO, Cs2O, and SrO for CO2 hydrogenation to methanol, focusing on the effect of synthesis methods.
Mohammad Sadegh Arabahmadi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Green methanol fuel production by CO2 conversion over Cr2O3-based Al2O3-promoted Cu-ZnO catalysts
Discover Applied SciencesPrecipitation method was employed to synthesize catalysts featuring Cu-ZnO on Cr2O3 support. Aluminum oxide (AI2O3) was incorporated in varying amounts to investigate its role as a promoter.
Israf Ud Din +7 more
doaj +1 more source