Results 31 to 40 of about 17,125 (231)

Mechanisms of functional disoreders of erythrocytes in experimental phenylhydrazine-induced methemoblobinemia

Бюллетень сибирской медицины, 2005
It was established that methemoglobiemia in experimental rats induced by one intraperitoneal injection of phenylhydrazine chloride (DL50), for a long time (up to 21 days after the injection of the drug) is accompanied by disorders in functional ...
I. A. Shprling, V. V. Novitsky, N. V. Ryazantseva, O. N. Filippova, N. M. Shevtsova, O. A. Rogov, V. V. Bas   +6 more
doaj   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Avaliação laboratorial da toxicidade molecular em eritrócitos talassêmicos Laboratorial evaluation of molecular toxicity in thalassemic erythrocytes

Revista Brasileira de Hematologia e Hemoterapia, 2006
Oxygen-derived free radical damage is associated with the molecular toxicity of hemoglobin. Especially in thalassemia syndromes, this toxicity has a relationship with "free" alpha globin concentrations.
Paulo Cesar Naoum, Sheldon S. S. Querino, Nathália M. Cury, Cristiane G. Toledo, Flávio Augusto Naoum   +4 more
doaj   +1 more source

From variant detection to interpretation in idiopathic erythrocytosis: A structured approach applied to a clinical cohort

British Journal of Haematology, EarlyView.
Targeted next‐generation sequencing combined with a structured interpretative framework integrating gene–disease validity, population data, computational predictions, ACMG criteria and structural modelling enabled prioritisation of rare variants in idiopathic erythrocytosis, highlighting the genetic heterogeneity and biological complexity underlying ...
Alessandra Giannella, Fabrizio Vianello, Simone Zoletto, Arianna Magrini, Ilaria Gianesello, Gianni Binotto, Nicolo’ Danesin, Jessica Ceccato, Giulia Gualtiero, Maria Piazza, Samuela Carraro, Valeria Carabotta, Francesco Cinetto, Alessandro Cellini, Marco Carraro, Carmela Gurrieri, Laura Pavan, Francesco Piazza, Andrea Visentin, Walter Ageno, Livio Trentin, Giulio Ceolotto   +21 more
wiley   +1 more source

Methaemoglobinaemia: From pathophysiology to contemporary clinical management

British Journal of Haematology, EarlyView.
Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley   +1 more source

Acute freshwater CO2 exposure does not impair seawater transfer in three different sizes of Atlantic salmon (Salmo salar) subjected to different photoperiod manipulations

Journal of Fish Biology, EarlyView.
Abstract There is a growing interest in Atlantic salmon (Salmo salar) aquaculture to extend the time fish are reared in freshwater (FW) recirculating aquaculture systems (RAS), producing larger FW salmon that can then be induced to undergo smoltification before transfer into marine net pens for grow‐out and harvest.
Le Thi Hong Gam, Daniel W. Montgomery, Daniel S. Laronde, Rachael Mackinnon, Jeffrey G. Richards, Colin J. Brauner   +5 more
wiley   +1 more source

Time‐dependent laryngeal desensitisation following topical lidocaine and prilocaine application in cats: a randomised controlled study

Journal of Small Animal Practice, EarlyView.
Objectives To compare the effects of topical prilocaine and lidocaine, relative to topical 0.9% sodium chloride, on laryngeal reactivity in anaesthetised cats prior to endotracheal intubation. Materials and Methods In this prospective, randomised, controlled, double‐blind study, 24 healthy adult cats were enrolled and allocated to topical prilocaine ...
A. Gölgeli Bedir, L. E. Yanmaz, Y. Akçora, Ç. Özkalıpçı, Ö. T. Orhun, Y. Kocaman, S. Okur   +6 more
wiley   +1 more source

Carboxyhemoglobin and methemoglobin levels to diagnose hemolysis in patients supported with mechanical circulatory support devices

JHLT Open
Background: Decreased systemic oxygen delivery derived from gas exchange abnormalities in severe hemolysis complicates patients requiring mechanical circulatory support devices.
Ingrid L. Rodgers, APRN, CRNA, Daniel S. Yip, MD, Parag C. Patel, MD, Cesar A. Keller, MD   +3 more
doaj   +1 more source

AAPH-induced oxidative damage reduced anion exchanger 1 (SLC4A1/AE1) activity in human red blood cells: protective effect of an anthocyanin-rich extract

Frontiers in Physiology, 2023
Introduction: During their lifespan in the bloodstream, red blood cells (RBCs) are exposed to multiple stressors, including increased oxidative stress, which can affect their morphology and function, thereby contributing to disease.Aim: This ...
Alessia Remigante, Sara Spinelli, Giuseppe Tancredi Patanè, Davide Barreca, Elisabetta Straface, Lucrezia Gambardella, Giuseppina Bozzuto, Daniele Caruso, Giuseppe Falliti, Silvia Dossena, Angela Marino, Rossana Morabito   +11 more
doaj   +1 more source

Septic Shock and Prognosis in Dogs and Cats With Sepsis—Consensus Definition and Clinical Criteria

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Death from sepsis results from progressive organ dysfunction. Early recognition of increased illness severity or deterioration in clinical status enables timely interventions that can improve outcomes. We aimed to define septic shock by consensus and to use the existing literature to identify associated clinical and clinicopathologic ...
Robert Goggs, Stefano Cortellini, Amy E. DeClue, Massimo Giunti, Kate Hopper, Julie M. Menard, Rodrigo C. Rabelo, Elizabeth A. Rozanski, Claire R. Sharp, Deborah C. Silverstein, Virginia Sinnott‐Stutzman, Giacomo Stanzani, John Bourgeois, Erik Fausak   +13 more
wiley   +1 more source