Results 81 to 90 of about 8,393 (209)

Therapeutic intervention strategies in frontotemporal dementia: drug development pipeline

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 4, October/December 2026.
Abstract Frontotemporal dementia (FTD) is the second most common cause of early‐onset dementia after Alzheimer's disease, characterized by substantial genetic, clinical, and pathological heterogeneity. Despite progress in understanding its pathophysiology, no disease‐targeted therapies (DTTs) have been approved to date.
Federica Perrone, Nicoletta Locuratolo, Elena Carbone, Marisa Cappella, Roberto Rivabene, Elisa Fabrizi, Giuseppina Talarico, Nicola Vanacore, Eleonora Lacorte, Paola Piscopo   +9 more
wiley   +1 more source

Organic Nitrate-Induced Methemoglobinemia

, 1989
Metabolism of organic nitrates results in the formation of inorganic nitrites that can oxidize hemoglobin to methemoglobin. Clinical trials have investigated the risk of developing methemoglobinemia during the therapeutic use of organic nitrates.
Jon W. Buenger, Vincent F. Mauro
core   +1 more source

A Case Report of Acute-on-Chronic Methemoglobinemia

Clinical Practice and Cases in Emergency Medicine
Introduction: Methemoglobinemia is a rare hematologic disorder of hemoglobin, in which iron contained within the heme moiety becomes oxidized from ferrous iron to ferric iron at a concentration greater than 1% in the blood.
Gabriel Lathrop, Rodney Fullmer
doaj   +1 more source

Severe Treatment-Resistant Methemoglobinemia of Unknown Etiology With Recurrence

Case Reports in Critical Care
Discussion: We report a case of a 25-year-old female with repeated admissions with methemoglobinemia. This case highlights the potential for refractory methemoglobinemia requiring repeated treatment, and the importance of longer periods of close ...
James Ainsworth, Suresh Pillai
doaj   +1 more source

Nitric oxide generation from nitrate at the cobalt center

Bulletin of the Korean Chemical Society, Volume 47, Issue 9, Page 1058-1062, September 2026.
Deoxygenation of a cobalt(II) nitrate complex with CO(g) or PPh3 yields a Co(NO)(NO2) species, which can alternatively be generated from a cobalt mononitrosyl complex, featuring a distinct {CoNO}8 core. Abstract Herein, we report the synthesis and reactivity of the cobalt(II) nitrate complex, (acriPNP)Co(NO3) (2).
Jeewon Chun, Yunho Lee
wiley   +1 more source

Methemoglobinemia-Induced Acute Kidney Injury

, 2013
IntroductionMethemoglobinemia refers to the presence of increased levels of methemoglobin (Fe3+) in the blood. Methemoglobinemia can cause cyanosis, dyspnea, fatigue, seizure, arrhythmia, coma, and even death. Although methemoglobinemia is shown to cause
Vachharajani, Tushar, Nayer, Ali, Soberon, Daniel J, Asif, Arif, Qureshi, Amir H   +4 more
core   +1 more source

Development of Antimicrobial AgNPs‐Coated Polydioxanone Sutures Using Low‐Pressure Plasma: Physicochemical Characterization and In Vitro Evaluation

Macromolecular Materials and Engineering, Volume 311, Issue 9, September 2026.
AgNPs‐coated PDO sutures were developed by low‐pressure plasma treatment, achieving homogeneous nanoparticle deposition without any significant changes in the polymer's physicochemical properties. The sutures exhibited controlled silver release, activity against S. aureus and E.
Esra Bozkaya
wiley   +1 more source

Food-induced methemoglobinemia : a systematic review

, 2022
Methemoglobinemia is a sporadic, potentially fatal disease of poor tissue oxygenation in which ferrous hemoglobin (Fe 2+) is oxidized to the ferric (Fe3+) state, rendering it incapable of binding oxygen (O2). Fortunately, it is diagnosable and treatable.
Kuchi, Nikhil (S35694), Xu, E., Gunja, N., McNulty, Richard (R19396)   +3 more
core   +1 more source

Refractory hypoxia and saturation gap in a COVID-19 patient

Practical Laboratory Medicine
Acquired methemoglobinemia, predominantly due to oxidizing medications occurs when heme iron in hemoglobin is oxidized from ferrous to ferric ion and binds oxygen irreversibly leading to functional anemia, cyanosis, and tissue hypoxia.
Abidah Mobarak, Subashini C. Thambiah, Ana Daliela Masiman, Intan Nureslyna Samsudin, Yin Ye Lai   +4 more
doaj   +1 more source

Methemoglobinemia after Local Anesthesia with Prilocaine: A Case Report

, 2016
Introduction: Methemoglobinemia due to local anesthesia is a rare phenomenon. Grey–blue cyanosis that is unresponsiveto oxygen therapy after the administration of local prilocaine should be considered with methemoglobinemia due to localanesthesia, and ...
Doğan, Halil, Şimşek, Cem, Koçak, Mehmet, Yazıcıoğlu, Mustafa, Özüçelik, Doğaç Niyazi   +4 more
core   +1 more source