Results 201 to 210 of about 82,122 (259)

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino   +2 more
wiley   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher   +8 more
wiley   +1 more source

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite   +10 more
wiley   +1 more source

Increased Risk of Environmental and Endemic Infectious Diseases in Sjögren's Disease: A Retrospective Analysis (2015–2023)

open access: yesACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Sjögren's disease (SjD) is a chronic autoimmune disease with a complex etiology, where pathogens may influence disease development or progression. Although SjD is not communicable, environmental and endemic pathogen exposures may influence its onset or progression.
Swetha K. Shankar   +3 more
wiley   +1 more source

3D‐Printable, Biodegradable, and Conductive/Piezoionic Hydrogel ‘E‐Skin’ With Robust Antibacterial Properties for Wound Healing and Wireless Human‐Machine Interface Sensing

open access: yesAdvanced Functional Materials, Volume 36, Issue 63, 6 August 2026.
A multifunctional MXene‐integrated GelMA/alginate hydrogel reinforced with TEMPO‐modified nanocellulose is engineered via dynamic covalent, ionic, and hydrogen bonding. The resulting piezoelectric, adhesive, antimicrobial, and 3D‐printable patch enables motion sensing and accelerates wound healing by promoting keratinocyte migration and collagen ...
Myoungjoon Jeon   +11 more
wiley   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

open access: yesAdvanced Materials, Volume 38, Issue 48, 26 August 2026.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase   +6 more
wiley   +1 more source

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