Results 71 to 80 of about 21,871,524 (296)

The Distribution of Mobile Genetic Elements (MGEs) in MRSA CC398 Is Associated with Both Host and Country. [PDF]

, 2011
Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S.
Moodley, Arshnee, Voss, Andreas, Hinds, J., Jodi A. Lindsay, Hinds, Jason, Lindsay, J.A., Gould, Katherine A., Denis, O., Gould, Katherine A, Adam A. Witney, Moodley, A., Lindsay, Jodi A., Witney, A.A., Gould, KA, Broens, EM, Broens, Els M, Alex J. McCarthy, Gould, K.A., Olivier Denis, Broens, Els M., Moodley, A, Voss, A., Witney, AA, Guardabassi, L., Arshnee Moodley, Broens, E.M., Witney, Adam A, McCarthy, A.J., Els M. Broens, McCarthy, AJ, Lindsay, JA, Denis, O, Katherine A. Gould, Witney, Adam A., Hinds, J, Guardabassi, Luca, Lindsay, Jodi A, Guardabassi, L, McCarthy, Alex J., Jason Hinds, Andreas Voss, Denis, Olivier, Luca Guardabassi, McCarthy, Alex J, Voss, A   +44 more
core   +2 more sources

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Identification of a Staphylococcus aureus transposon (Tn4291) that carries the methicillin resistance gene(s) [PDF]

Journal of Bacteriology, 1988
We isolated a transposon (Tn4291) that carries the resistance gene(s) for methicillin in a secondary insertion site on the penicillinase plasmid pI524. Transposition of Tn4291 into pI524 occurred during the transduction of the tetracycline resistance plasmid pSN1 from a methicillin-resistant donor into a recipient that carried the mec allele in the ...
D L, Trees, J J, Iandolo
openaire   +2 more sources

The impact of glycopeptide- and methicillin- resistance on "Staphylococcus aureus" and its virulence in localized and systemic infections [PDF]

, 2007
Adaptation of bacteria to their environment is a necessity to keep their fitness and survival under limiting conditions. In chapter I of this work we demonstrated that adaptation of glycopeptide-resistant S.
Karaüzüm, Hatice
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Clinical and Microbiological Determinants of Outcome in Staphylococcus aureus Bacteraemia. [PDF]

, 2010
Staphylococcus aureus bacteraemia (SAB) is commonly complicated by metastatic infection or relapse after treatment. Objectives. The study aim was to determine the role of bacterial, host, and management factors in development of complicated SAB. Methods.
Karen Walker-Bone, Lindsay, J., Llewelyn, M, Heath, I., Curtis, S., Jodi Lindsay (378699), Lindsay, J, Gillian Baker (16048691), Sally Curtis (11260241), Cubbon, M., Paul, J., John Paul (744142), Llewelyn, M., James Price (6728021), Enright, M.C., Martin Llewelyn (4461757), James Price, Mark C Enright (16048700), Walker-Bone, K., Enright, MC, Curtis, S, Mark C Enright, Martin Llewelyn, Ian Heath, Marc Cubbon, Walker-Bone, K, Price, J., Gillian Baker, Jodi Lindsay, Karen Walker-Bone (2634085), Mark C. Enright, John Paul, Baker, G., Paul, J, Cubbon, M, Sally Curtis, Ian Heath (16048694), Marc Cubbon (16048697), Enright, Mark, Baker, G, Price, J, Heath, I   +41 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Methicillin-resistant Staphylococcus aureus contamination and distribution in patient’s care environment at Muhimbili National Hospital, Dar es Salaam-Tanzania

BMC Research Notes, 2018
Objective Environmental contamination with methicillin-resistant Staphylococcus aureus in routine medical care settings poses an increased risk of health care associated infections through cross-transmission. This study aimed at determining the magnitude
Emmanuel James Nkuwi, Fatima Kabanangi, Agricola Joachim, Sima Rugarabamu, Mtebe Majigo   +4 more
doaj   +1 more source