Results 141 to 150 of about 203,131 (298)

Distribution and Antimicrobial Resistance of Pathogenic Bacteria in Patients With Sternal Osteomyelitis

open access: yesiLABMED, EarlyView.
This study conducted a retrospective analysis of microbiological culture results and antimicrobial resistance patterns in patients with sternal osteomyelitis at a tertiary medical center. The primary pathogens causing sternal osteomyelitis were gram‐positive bacteria. Infections with multidrug‐resistant organisms were also relatively common among these
Yumin Yang   +5 more
wiley   +1 more source

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

open access: yesInterdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan   +2 more
wiley   +1 more source

Mortality after broad‐ versus narrow‐spectrum antibiotic treatment for patients with nursing and healthcare‐associated pneumonia: A nationwide retrospective cohort study

open access: yesJournal of Hospital Medicine, EarlyView.
Abstract Background Nursing and healthcare‐associated pneumonia (NHCAP) is defined as pneumonia occurring in individuals with frequent healthcare contact, such as residents of care facilities or patients with impaired activities of daily living. The effectiveness of broad‐spectrum antibiotics in treating NHCAP remains unclear.
Jumpei Taniguchi   +4 more
wiley   +1 more source

First report of sasX-positive methicillin-resistant Staphylococcus aureus in Japan [PDF]

open access: bronze, 2017
Hidemasa Nakaminami   +8 more
openalex   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

open access: yesJournal of Orthopaedic Research, EarlyView.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon   +9 more
wiley   +1 more source

Vanquish the vancomycin trough: a real‐world experience of pharmacist‐driven Bayesian software‐guided dosing using area under the curve (AUC) targets

open access: yesJournal of Pharmacy Practice and Research, EarlyView.
Abstract Background A tertiary healthcare institution, located in New Zealand, switched from targeting trough vancomycin concentrations to 24‐h area under the concentration‐time curve (AUC24), facilitated by pharmacists using a Bayesian software‐guided approach.
Duncan Yorkston   +6 more
wiley   +1 more source

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