Results 61 to 70 of about 1,091,177 (248)

The Distribution of Mobile Genetic Elements (MGEs) in MRSA CC398 Is Associated with Both Host and Country. [PDF]

, 2011
Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S.
Moodley, Arshnee, Voss, Andreas, Hinds, J., Jodi A. Lindsay, Hinds, Jason, Lindsay, J.A., Gould, Katherine A., Denis, O., Gould, Katherine A, Adam A. Witney, Moodley, A., Lindsay, Jodi A., Witney, A.A., Gould, KA, Broens, EM, Broens, Els M, Alex J. McCarthy, Gould, K.A., Olivier Denis, Broens, Els M., Moodley, A, Voss, A., Witney, AA, Guardabassi, L., Arshnee Moodley, Broens, E.M., Witney, Adam A, McCarthy, A.J., Els M. Broens, McCarthy, AJ, Lindsay, JA, Denis, O, Katherine A. Gould, Witney, Adam A., Hinds, J, Guardabassi, Luca, Lindsay, Jodi A, Guardabassi, L, McCarthy, Alex J., Jason Hinds, Andreas Voss, Denis, Olivier, Luca Guardabassi, McCarthy, Alex J, Voss, A   +44 more
core   +2 more sources

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

Angewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu, Wei Feng, Hongquan Zhang, X. Chris Le   +3 more
wiley   +2 more sources

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Livestock-associated methicillin resistant Staphylococcus aureus in pigs - prevalence, risk factors and transmission dynamics [PDF]

, 2011
In 2004, an association between human carriage of methicillin resistant Staphylococcus aureus (MRSA) and contact with pigs was found. To assess the implications of this finding for veterinary and public health more insight into the prevalence, risk ...
Broens, E.M.
core  

Pan-European early switch/early discharge opportunities exist for hospitalised patients with methicillin-resistant Staphylococcus aureus complicated skin and soft-tissue infections [PDF]

, 2014
The objective was to document pan-European real-world treatment patterns and healthcare resource use and estimate opportunities for early switch (ES) from intravenous (IV) to oral antibiotics and early discharge (ED) in hospitalised patients with ...
Solem, C.T., Haider, S., Macahilig, C., D. Simoneau, W. Lawson, C. Macahilig, Li, J.Z., Stephens, J.M., J.Z. Li, C. Eckmann, S. Haider, R. Chambers, J.M. Stephens, Simoneau, D., Eckmann, C., D. Nathwani, Lawson, W., C.T. Solem, Nathwani, D., Chambers, R., Li, J. Z.   +20 more
core   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Global distribution and diversity of ovine-associated Staphylococcus aureus [PDF]

, 2014
Staphylococcus aureus is an important pathogen of many species, including sheep, and impacts on both human and animal health, animal welfare, and farm productivity. Here we present the widest global diversity study of ovine-associated S.
Smith, Edward M., Green, Laura E., Green, Laura E.; id_orcid, Manley, Grace, Needs, Polly F.   +4 more
core   +1 more source

STUDYING THE FREQUENCY OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS THROUGH THE MOLECULAR DETECTION OF MECA

The Iraqi Journal of Medical Sciences, 2016
Background: Methicillin-resistant Staphylococcus aureus is a major cause of serious nosocomial infections and it is very important to have a reliable test to detect these bacteria.
Rafeef Y. Rasheed, Ahmed S. Abdulamir
doaj   +4 more sources

Nasal carriage rate, associated factors, and antimicrobial susceptibility patterns of methicillin resistance Staphylococcus aureus among pre-clinical undergraduate students at the College of Health and Medical Sciences, Haramaya University, Ethiopia

Frontiers in Public Health
BackgroundStaphylococcus aureus nasal carriage has been linked to higher rates of infection and morbidity. People with Methicillin-resistant Staphylococcus aureus can be a potential source of infection for others.
Fitsum Weldegebreal, Fitsum Weldegebreal, Kedir Urgesa, Firayad Ayele, Kasahun Bogale, Taddese Shume, Mohammed Ahmed, Sileshi Debebe, Fikru Tebeje, Haftu Asmerom, Tewodros Tesfa, Shambel Mekonnen   +11 more
doaj   +1 more source