Results 111 to 120 of about 501,506 (307)

The d-amino acid oxidase of Neurospora [PDF]

open access: yes, 1944
Among artificially produced mutants of the mold Neurospora have been found strains lacking the ability to synthesize specific amino acids (1, 2). In the course of biochemical and genetic studies of this group of mutants it was observed that some of the ...
Horowitz, N. H.
core  

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

open access: yes, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE   +4 more
core   +4 more sources

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

open access: yesAdvanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao   +6 more
wiley   +1 more source

Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins. [PDF]

open access: yes, 2018
Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Barry, Natasha A   +5 more
core  

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du   +18 more
wiley   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

open access: yesAdvanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su   +4 more
wiley   +1 more source

Evaluation of performance, antioxidant status, morphology and microbiology of the ileum and the content of elements in the liver of broiler chickens fed with organic forms of zinc, copper, manganese and iron

open access: yesĀsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
Ration composition and in particular, the amount of trace elements in the feed has become especially important to increase the economic efficiency and health of the poultry.
Mohammad Pourmostafa   +4 more
doaj  

Localization and synthesis of prenylquinones in isolated outer and inner envelope membranes from spinach chloroplasts [PDF]

open access: yes, 1985
The prenylquinone content and biosynthetic capabilities of membrane fractions enriched in outer and inner envelope membranes from spinach chloroplasts were analyzed.
Bligh   +23 more
core   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu   +11 more
wiley   +1 more source

Estimation of Optimal and Maximum Standardized Ileal Digestible Methionine Requirements Based on Performance for Male Broilers Aged 0 to 21 Days

open access: yesAnimals
Two experiments were conducted with Ross 308 male broiler chickens to determine the standardized ileal digestible (SID) methionine (Met) requirement for maximum weight gain during the starter (0 to 10 days) and grower (10 to 21 days) phases.
Su-Hyun An, Changsu Kong
doaj   +1 more source

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