Results 131 to 140 of about 299,228 (260)

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes

Angewandte Chemie, EarlyView.
Biological C–H methylation proceeds through radical pathways mediated by one‐electron redox cofactors, yet no synthetic model has reproduced this reactivity. Here, we report the first isolable Cu(II/III)–methyl complexes that mediate C–H methylation through hydrogen atom transfer and methyl radical rebound.
Emily N. Doss, Curtis E. Moore, Shiyu Zhang   +2 more
wiley   +2 more sources

Chemotherapy in Combination With Methionine Restriction Induced A Complete Response in a Patient With Recurrent Metastatic Tongue Squamous-Cell Carcinoma. [PDF]

Cancer Diagn Progn
Ishiguro T, Sato T, Han Q, Li S, Miyashi Y, Kang BM, Kim JS, Tsunoda T, Hoffman RM.   +8 more
europepmc   +1 more source

Oxidation Products of S-Adenosyl Methionine Probed by Infrared Multiple Photon Dissociation Spectroscopy. [PDF]

Chemphyschem
Bardaud JX, Jiang Y, Clavaguera C, Houée-Levin C, Berden G, Oomens J, Scuderi D.   +6 more
europepmc   +1 more source

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, EarlyView.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Comparison of amide proton transfer imaging and methionine PET for differentiating radiation necrosis and tumor recurrence after radiotherapy: A preliminary case series. [PDF]

Radiol Case Rep
Kadota T, Fukuda H, Kawanishi Y, Nakai E, Fukui N, Ueba T.   +5 more
europepmc   +1 more source

An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases

Angewandte Chemie, EarlyView.
State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson, Ulrich Kauhl, Martin R. Edelmann, Florian P. Seebeck   +3 more
wiley   +2 more sources

Structures of the neutral amino acid transporter LAT4 provide insights into antitumor effects of its inhibitor tubeimoside-1. [PDF]

EMBO J
Ding D, Lu Y, Yang J, Chen H, Jiang P, Jin Y, Luo J, Wang G, Yin Y.   +8 more
europepmc   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

SIN-3 coregulator maintains adaptive capacity to different diets in Caenorhabditis elegans through vitamin B12. [PDF]

G3 (Bethesda)
Palladino F, Bedet C.
europepmc   +1 more source

THE EFFECT OF METHIONINE AND METHIONINE PRECURSORS ON THE GROWTH OF STREPTOCOCCUS LACTIS [PDF]

Journal of Bacteriology, 1955
D E, KIZER, M L, SPECK, L W, AURAND
openaire   +2 more sources