Results 1 to 10 of about 43,956,264 (204)

Excess S-adenosylmethionine inhibits methylation via catabolism to adenine [PDF]

Communications Biology, 2022
S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.
Kazuki Fukumoto, Kakeru Ito, Benjamin Saer, George Taylor, Shiqi Ye, Mayu Yamano, Yuki Toriba, Andrew Hayes, Hitoshi Okamura, Jean-Michel Fustin   +9 more
doaj   +3 more sources

Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

Cell Metabolism, 2023
Summary There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major organs of the body.
Carlos Matute, Patricia Aspichueta, Maria Luz Martinez Chantar   +2 more
exaly   +2 more sources

S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

Cell Reports, 2017
Summary: S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA and histone methylation, tuning regulation of gene expression. Appropriate intracellular SAM levels must be maintained, because methyltransferase reaction rates
Hiroki Shima, Mitsuyo Matsumoto, Yuma Ishigami, Masayuki Ebina, Akihiko Muto, Yuho Sato, Sayaka Kumagai, Kyoko Ochiai, Tsutomu Suzuki, Kazuhiko Igarashi   +9 more
doaj   +2 more sources

S-Adenosylmethionine Synthetase Is Required for Cell Growth, Maintenance of G0 Phase, and Termination of Quiescence in Fission Yeast

iScience, 2018
Summary: S-adenosylmethionine is an important compound, because it serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids.
Takeshi Hayashi, Takayuki Teruya, Romanas Chaleckis, Susumu Morigasaki, Mitsuhiro Yanagida   +4 more
doaj   +2 more sources

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

mSystems, 2019
To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya, Mansi Sharma, Charles Packianathan, Barry P. Rosen, Philippe Leprohon, Marc Ouellette   +5 more
doaj   +2 more sources

Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses.

PLoS Biology, 2019
We present a selection design that couples S-adenosylmethionine-dependent methylation to growth. We demonstrate its use in improving the enzyme activities of not only N-type and O-type methyltransferases by 2-fold but also an acetyltransferase of another
Hao Luo, Anne Sofie L Hansen, Lei Yang, Konstantin Schneider, Mette Kristensen, Ulla Christensen, Hanne B Christensen, Bin Du, Emre Özdemir, Adam M Feist, Jay D Keasling, Michael K Jensen, Markus J Herrgård, Bernhard O Palsson   +13 more
doaj   +2 more sources

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

Biotechnology for Biofuels, 2019
Background S-Adenosylmethionine (SAM) is a critical cofactor involved in many biochemical reactions. However, the low fermentation titer of SAM in methionine-free medium hampers commercial-scale production.
Liying Ruan, Lu Li, Dian Zou, Cong Jiang, Zhiyou Wen, Shouwen Chen, Yu Deng, Xuetuan Wei   +7 more
doaj   +2 more sources

Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine

Developmental Cell, 2018
Masayuki Miura, Fumiaki Obata
exaly   +2 more sources

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism

Science, 2023
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one ...
Vanha N. Pham, Kevin J. Bruemmer, J. D. Toh, Eva J. Ge, Logan Tenney, Carl C. Ward, Felix A. Dingler, Christopher L. Millington, C. García-Prieto, Mia C. Pulos-Holmes, Nicholas T. Ingolia, Lucas B. Pontel, M. Esteller, Ketan J. Patel, D. Nomura, Christopher J. Chang   +15 more
semanticscholar   +1 more source

S-Adenosylmethionine: More than Just a Methyl Donor

Natural product reports (Print), 2023
S-Adenosyl-l-methionine (SAM) is a naturally occurring trialkyl sulfonium molecule that is typically associated with biological methyltransfer reactions.
Yu-Hsuan Lee, Da-An Ren, Byung-sun Jeon, Hung-Wen Liu   +3 more
semanticscholar   +1 more source