Results 1 to 10 of about 21,123,172 (247)
Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]
PLoS ONE, 2013 In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh +2 more
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Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. [PDF]
PLoS ONE, 2016 Folate deficiency is generally accepted as a potential direct or indirect risk factor for diseases including spina bifida, coronary heart diseases, malfunctions of the central nervous system, and cancer. The direct inclusion of folates in the methylation
Markus Kopp +3 more
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Metabolites, 2022 S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced de novo via the methionine cycle. The demethylation of SAM produces S-adenosylhomocysteine (SAH), an inhibitor of methyltransferases and the precursor of ...
Aida Corrillero Bravo +12 more
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5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]
PLoS ONE, 2013 Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham +5 more
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ACCUMULATION OF S-ADENOSYLMETHIONINE BY MICROORGANISMS [PDF]
Journal of Bacteriology, 1962 Gawel , L. J. (Oregon State University, Corvallis), J. R. Turner, and L. W. Parks . Accumulation of S-adenosylmethionine by microorganisms. J. Bacteriol. 83: 497–499. 1962.—A series of microorganisms selected to represent a variety of microbial types was cultured under conditions ...
L J, GAWEL, J R, TURNER, L W, PARKS
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iScience, 2018 Summary: S-adenosylmethionine is an important compound, because it serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids.
Takeshi Hayashi +4 more
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S-adenosylmethionine metabolism and liver disease
Annals of Hepatology, 2013 Methionine is an essential amino acid that is metabolized mainly by the liver where it is converted to S-adenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase.
José M. Mato +2 more
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Ademethionine in the treatment of fatigue in liver diseases: a systematic review [PDF]
Терапевтический архив, 2019 Fatigue has a significant effect on the condition of patients with liver disease. Ademethionine is considered one of the most promising drugs for its treatment. Aim.
K L Raikhelson, E A Kondrashina
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PLoS Pathogens, 2011 Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping.
Etienne Decroly +12 more
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S-Adenosylmethionine in a Neuroblastoma [PDF]
Pediatric Research, 1971 Soluble extracts of a neuroblastoma did not require additional methyl donor, S-adenosyl-L-methionine (SAM), for maximal catechol O-methltransferase activity. Prior dialysis of the extract resulted in complete loss of enzymatic activity which could be partially recovered by addition of SAM to the reaction mixture.
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