Results 41 to 50 of about 43,956,264 (204)

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

S-adenosylmethionine treatment prevents carbon tetrachloride—inducedS-adenosylmethionine synthetase inactivation and attenuates liver injury

, 2007
Administration of carbon tetrachloride to rats resulted in induction of hepatic fibrosis and a 60% reduction of hepatic S-adenosylmethionine synthetase activity without producing any significant modification of hepatic levels of S-adenosylmethionine ...
Mato, José M., Álvarez, Luis, Fernando Corrales, Joan Caballería, Albert Parés, Hernán Andreu, Pajares, María A., América Giménez, Luis Alvarez, Corrales, Fernando, Joan Rodés, José M. Mato, María A. Pajares   +12 more
core   +1 more source

The Impact of One Carbon Metabolism on Histone Methylation

Frontiers in Genetics, 2019
The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-adenosyl methionine (SAM), which is also the methyl-donating substrate of ...
Magdalini Serefidou, Anuroop Venkateswaran Venkatasubramani, Axel Imhof   +2 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Associations of S-Adenosylmethionine and S-Adenosylhomocysteine with Hepatocellular Carcinoma

Metabolites
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, increasingly arising in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Naana N. Yalley, Sebastian M. Armasu, Winnie Z. Fan, Irene K. Yan, Fowsiyo Y. Ahmed, Per Stål, Lewis R. Roberts, Tushar Patel, Samuel O. Antwi   +8 more
doaj   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Evaluation of chemical and diastereoisomeric stability of S-adenosylmethionine in aqueous solution by capillary electrophoresis

, 2005
Capillary electrophoresis was used for monitoring the stability of S-adenosylmethionine in aqueous solution under different conditions of storage and incubation used for "in vitro" and "in vivo" experiments, by evaluating both the entity of degradation ...
S Scarpa, C Desiderio, A Fuso, A De Rossi, F D'Anselmi, RA Cavallaro   +5 more
core   +2 more sources

Protective role of S-Adenosylmethionine against fructose-induced oxidative damage in obesity

Journal of Mind and Medical Sciences, 2017
Introduction. It has been shown that S-adenosylmethionine (S-AMe) stimulates glutathione synthesis and increases cell resistance to the cytotoxic action of free radicals and pro-inflammatory cytokines. The aim of this study was to determine the effect of
Kameliya Zh Bratoeva, Mariya A. Radanova, Albena V. Merdzhanova, Ivan S. Donev   +3 more
doaj   +1 more source

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. [PDF]

PLoS ONE, 2009
BACKGROUND:Countries worldwide recommend women planning pregnancy to use daily 400 microg of synthetic folic acid in the periconceptional period to prevent birth defects in children.
Régine P Steegers-Theunissen, Sylvia A Obermann-Borst, Dennis Kremer, Jan Lindemans, Cissy Siebel, Eric A Steegers, P Eline Slagboom, Bastiaan T Heijmans   +7 more
doaj   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source