The Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine in Normal and Neoplastic Cells [PDF]
, 1980 Altered patterns of methylation have been shown in both ribosomal and transfer RNA isolated from cancer cells. In contrast to the elevated activity of the methyltransferases responsible for this modification, hypomethylation appears as a general ...
Godburn, Kathryn Elizabeth
core +2 more sources
S-Adenosylmethionine for osteoarthritis of the knee or hip [PDF]
, 2008 BACKGROUND: Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. S-Adenosylmethionine may be a viable treatment option but the evidence about its effectiveness and safety is equivocal ...
Peter Jüni +7 more
core +3 more sources
环境与职业医学, 2023 BackgroundArsenic exposure can lead to liver dysfunction, liver steatosis, hepatitis, liver fibrosis, and other liver injuries, but its mechanism is still unclear and effective treatment methods are lacking.ObjectiveTo investigate the potential ...
Lu MA +5 more
doaj +1 more source
The mechanism of 7,8-diaminopelargonate synthase; the role of S-adenosylmethionine as the amino donor [PDF]
, 2003 The mechanism of 7,8-diaminopelargonate synthase was studied. The role of S-adenosylmethionine as the amino donor was discussed. It was found that the product of the first transamination step in the reaction catalyzed by diaminopelargonate (DAPA ...
Webster, S +5 more
core +1 more source
S-Adenosylmethionine supplementation may reduce cancer-related fatigue. A prospective evaluation using the FACIT-F questionnaire in colon cancer patients undergoing oxaliplatin-based chemotherapy regimens [PDF]
, 2021 Background: Fatigue is a common distressing symptom for patients living with chronic or acute diseases, including liver disorders and cancer (Cancer-Related Fatigue, CRF). Its etiology is multifactorial, and some hypotheses regarding the pathogenesis are
Incorvaia L. +7 more
core +1 more source
Streamlined recycling of S-adenosylmethionine [PDF]
, 2019 S-adenosylmethionine (SAM)-dependent methyltransferase enzymes have significant synthetic potential, but their utility as biocatalysts has been limited by the availability of SAM. An elegant and simple method addressing this long-standing problem has now
Micklefield, Jason
core +1 more source
mSystems, 2019 To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya +5 more
doaj +1 more source
FERONIA receptor kinase interacts with S-adenosylmethionine synthetase and suppresses S-adenosylmethionine production and ethylene biosynthesis in Arabidopsis [PDF]
, 2015 Environmental inputs such as stress can modulate plant cell metabolism, but the detailed mechanism remains unclear. We report here that FERONIA (FER), a plasma membrane receptor-like kinase, may negatively regulate the S-adenosylmethionine (SAM ...
Li, Jianglin +13 more
core +1 more source
A natural riboswitch scaffold with self-methylation activity
Nature Communications, 2021 In humans, protein methyltransferase is responsible for RNA methylation using S-adenosylmethionine as a methyl group donor. Here the authors report a self-methylation activity of a bacterial riboswitch.
Laurin Flemmich +4 more
doaj +1 more source
Glucocorticoid regulation of hepatic S-adenosylmethionine synthetase gene expression [PDF]
, 1997 8 pages, 8 figures.The effects of glucocorticoids on the regulation of rat liver S-adenosylmethionine synthetase were studied in vivo and in two culture systems.
Pajares, María Ángeles +3 more
core +1 more source