Results 41 to 50 of about 21,123,172 (247)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

The Impact of One Carbon Metabolism on Histone Methylation

Frontiers in Genetics, 2019
The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-adenosyl methionine (SAM), which is also the methyl-donating substrate of ...
Magdalini Serefidou, Anuroop Venkateswaran Venkatasubramani, Axel Imhof   +2 more
doaj   +1 more source

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

Nature Communications, 2022
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras, Patricia Aspichueta   +28 more
doaj   +1 more source

Mini Review: Scientific Analysis of Radical S-Adenosylmethionine (SAM) Enzymes [PDF]

The radical S-Adenosylmethionine (SAM) superfamily of enzymes catalyzes a diverse range of reactions ranging from hydrogen abstraction to complicated multistep reactions such as insertions and rearrangements. The reactions they catalyze are utilized in a
Gallage H. D. N., Ariyaratne
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. [PDF]

PLoS ONE, 2009
BACKGROUND:Countries worldwide recommend women planning pregnancy to use daily 400 microg of synthetic folic acid in the periconceptional period to prevent birth defects in children.
Régine P Steegers-Theunissen, Sylvia A Obermann-Borst, Dennis Kremer, Jan Lindemans, Cissy Siebel, Eric A Steegers, P Eline Slagboom, Bastiaan T Heijmans   +7 more
doaj   +1 more source

Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle

eLife, 2022
The redox reagent dithiothreitol (DTT) causes stress in the endoplasmic reticulum (ER) by disrupting its oxidative protein folding environment, which results in the accumulation and misfolding of the newly synthesized proteins. DTT may potentially impact
Gokul G, Jogender Singh
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Accumulation of S-Adenosylmethionine by Molds

Agricultural and Biological Chemistry, 1974
Aspergillus tamani accumulated about 20 μmoles of S-adenosylmethionine (SAM) in 1 g of dry cells when cultured secondarily in a medium containing more than 10 mm of l- methionine. The accumulation was not so high when l-methionine was replaced by d- methionine. Addition of nucleic acid-related substances was not effective for the accumulation. Addition
KUSAKABE, Hitoshi, KUNINAKA, Akira, YOSHINO, Hiroshi   +2 more
openaire   +1 more source

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism [PDF]

, 2023
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one ...
Millington, Christopher L, Bruemmer, Kevin J, Pontel, Lucas B, Ge, Eva J, Toh, Joel DW, Esteller, Manel, Ingolia, Nicholas T, Dingler, Felix A, Pulos-Holmes, Mia C, Nomura, Daniel K, Ward, Carl C, Garcia-Prieto, Carlos A, Patel, Ketan J, Pham, Vanha N, Chang, Christopher J, Tenney, Logan   +15 more
core   +1 more source