Results 61 to 70 of about 43,956,264 (204)

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring

Nature Chemical Biology, 2017
Despite containing an α-amino acid, the versatile cofactor S-adenosylmethionine (SAM) is not a known building block for non-ribosomal peptide synthetase (NRPS) assembly lines.
Li Zha, Yin-Di Jiang, Matthew T. Henke, Matthew R. Wilson, Jennifer X. Wang, N. Kelleher, E. Balskus   +6 more
semanticscholar   +1 more source

The mechanism of 7,8-diaminopelargonate synthase; the role of S-adenosylmethionine as the amino donor

, 2003
The mechanism of 7,8-diaminopelargonate synthase was studied. The role of S-adenosylmethionine as the amino donor was discussed. It was found that the product of the first transamination step in the reaction catalyzed by diaminopelargonate (DAPA ...
Webster, S, Baxter, RL, Watt, R, Campopiano, DJ, Breen, RS, Brunton, M   +5 more
core   +1 more source

Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine

Cell Stress, 2021
S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing.
Yudong Sun, Jason W. Locasale
doaj   +1 more source

Die tRNA‐Modifikation Geranyl‐2‐thiouridin ermöglicht eine RNA‐Lipid Assoziation

Angewandte Chemie, EarlyView.
Wir berichten über die Herstellung mono‐ bis tri‐geranylierter RNA und über die Assoziation hydrophober RNA mit Membranen für einen künftigen effizienten Einbau von RNA in Liposomen. ZUSAMMENFASSUNG Die Verpackung von RNA in Lipid‐Nanopartikeln zum Schutz und Transport war für die Entwicklung von mRNA‐Impfstoffen und Medikamenten entscheidend.
Johannes Singer, Kathrin Halter, Chun‐Yin Chan, Thomas Carell   +3 more
wiley   +1 more source

Regulation of mammalian S-adenosylmethionine decarboxylase

, 1988
S-Adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of polyamines that is the rate limiting step in the formation of spermidine and spermine.
Pajunen, Antti, Shirahata, Akira, Kameji, Takaaki, Stanley, Bruce, Madhubala, Rentala, Pegg, Anthony E.   +5 more
core   +1 more source

Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC

Journal of Biological Chemistry, 2017
Ribosomally synthesized and posttranslationally modified peptide (RiPP) pathways produce a diverse array of natural products. A subset of these pathways depends on radical S-adenosylmethionine proteins to modify the RiPP-produced peptide.
Bulat Khaliullin, Richard S. Ayikpoe, M. Tuttle, J. Latham   +3 more
semanticscholar   +1 more source

Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis

Parasite, 2005
Biological effects of piroxicam, metamizol, and S-adenosylmethionine (S-AMET) have been tested in NMRI mice infected intraperitoneally with Trichomonas vaginalis. An intraperitoneal treatment during ten preinfection days with piroxicam (10 mg/Kg/day), or
Nogal-Ruiz J.J., Gómez-Barrio A., Escario J.A., Montero-Pereira D., Martínez-Fernández A.R.   +4 more
doaj   +1 more source

S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review

Annals of General Psychiatry, 2020
Background Major depressive disorder (MDD) is a recurrent illness with high rates of chronicity, treatment-resistance, and significant economic impact.
Alessandro Cuomo, Bruno Beccarini Crescenzi, Simone Bolognesi, Arianna Goracci, Despoina Koukouna, Rodolfo Rossi, Andrea Fagiolini   +6 more
doaj   +1 more source

Reversal of refractory epilepsy in an adult with GAMT deficiency: A case report and comparative literature review

Epilepsia Open, EarlyView.
Abstract Objective Guanidinoacetate methyltransferase (GAMT) deficiency is a rare autosomal recessive creatine biosynthesis disorder. Reports specifically focusing on adult patients remain scarce. Methods We report a 52‐year‐old female (the oldest documented case of GAMT deficiency to date) presenting with severe intellectual disability, refractory ...
Wei‐Hung Sung, Hsi Chen, Che‐Wei Hsu, Meng‐Han Tsai   +3 more
wiley   +1 more source

Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study

Frontiers in Pharmacology
BackgroundAmino acids are known to play critical roles in cancer metabolism and progression. Among them, taurine, S-adenosylmethionine (SAM), and cysteine have garnered particular attention due to their interconnected metabolic pathways.
Chenan Liu, Chenan Liu, Chenan Liu, Chenan Liu, Chenan Liu, Tong Liu, Tong Liu, Tong Liu, Tong Liu, Tong Liu, Yaping Wei, Jinyu Shi, Jinyu Shi, Jinyu Shi, Jinyu Shi, Jinyu Shi, Li Deng, Li Deng, Li Deng, Mengmeng Song, Hanping Shi, Hanping Shi, Hanping Shi, Hanping Shi, Hanping Shi   +24 more
doaj   +1 more source