Results 61 to 70 of about 15,844,621 (256)

Methylation studies of MBP and synthetic peptides by S-adenosylmethionine-MBP methyltransferase from bovine brain. [PDF]

, 1989
Methylation studies of MBP and synthetic peptides by S-adenosylmethionine-MBP methyltransferase from bovine ...
Frida. Grynspan (7963835)
core  

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Purification and characterization of s-adenosylmethionine synthetase from candida albicans [PDF]

, 1989
S-Adenosylmethionine (SAM) synthetases isolated from both the yeast and hyphal-phase of the dimorphic fungus, C. albicans, were partially purified using DEAE cellulose ion-exchange column chromatography.
Jones, Ward M.
core  

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

Nature Communications, 2022
High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.
Diego Sáenz de Urturi, Xabier Buqué, Begoña Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernández, Paula Olaizola, Beatriz Gómez-Santos, Maider Apodaka-Biguri, Francisco González-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis García-Rodríguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martín-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, María L. Martínez-Chantar, Rubén Nogueiras, Patricia Aspichueta   +28 more
doaj   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Protective role of S-Adenosylmethionine against fructose-induced oxidative damage in obesity

Journal of Mind and Medical Sciences, 2017
Introduction. It has been shown that S-adenosylmethionine (S-AMe) stimulates glutathione synthesis and increases cell resistance to the cytotoxic action of free radicals and pro-inflammatory cytokines. The aim of this study was to determine the effect of
Kameliya Zh Bratoeva, Mariya A. Radanova, Albena V. Merdzhanova, Ivan S. Donev   +3 more
doaj   +1 more source

Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle

eLife, 2022
The redox reagent dithiothreitol (DTT) causes stress in the endoplasmic reticulum (ER) by disrupting its oxidative protein folding environment, which results in the accumulation and misfolding of the newly synthesized proteins. DTT may potentially impact
Gokul G, Jogender Singh
doaj   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. [PDF]

PLoS ONE, 2009
BACKGROUND:Countries worldwide recommend women planning pregnancy to use daily 400 microg of synthetic folic acid in the periconceptional period to prevent birth defects in children.
Régine P Steegers-Theunissen, Sylvia A Obermann-Borst, Dennis Kremer, Jan Lindemans, Cissy Siebel, Eric A Steegers, P Eline Slagboom, Bastiaan T Heijmans   +7 more
doaj   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source