Results 71 to 80 of about 15,844,621 (256)

Biosynthese des vollständig gesättigten C16‐Homosesquiterpens Descartan durch Deprotonierung mit Cyclopropanierung

Angewandte Chemie, EarlyView.
Eine nicht‐kanonische C16‐Sesquiterpensynthase aus Morganella morganii produziert das ungewöhnliche Grundgerüst Descartan. Ihr Cyclisierungsmechanismus wurde mittels Isotopenmarkierungsexperimenten und DFT‐Berechnungen aufgeklärt. Gezielte Mutagenese veränderte die Enzymfunktion und führte zu alternativen Produkten, darunter Voltairen, dessen ...
Kexin Yang, Philip Troycke, Bernd Goldfuss, Michael Groll, Jeroen S. Dickschat   +4 more
wiley   +1 more source

The effect of S-adenosylmethionine on self-mutilation in a patient with Lesch-Nyhan disease [PDF]

, 2016
BACKGROUND: Lesch-Nyhan disease (LND) is an X-chromosomal disorder of purine metabolism characterized by hyperuricemia, dystonia, and self-mutilation, leading to an extremely high burden of disease in affected patients and families.
Pfiffner, Miriam, Matthias Lauber, Jean-Marc Nuoffer, Johannes Häberle, Miriam Pfiffner, Häberle, Johannes, Lauber, Matthias, Nuoffer, Jean-Marc, Barbara Plecko, Plecko, Barbara   +9 more
core   +1 more source

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, EarlyView.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

S-adenosylmethionine in rat liver cirrhosis [PDF]

, 1993
An experimental model of cirrhosis in rats, by means carbon tetrachloride (CCl4) and ethanol during two months, was used to assess the effectiveness of S-adenosylmethionine.
Cutrin, C, Menino, MJ, Parafita, MA, Carballo, C, Perez-Becerra, E, Barrio, E   +5 more
core  

S-adenosylmethionine decarboxylase from human placenta. [PDF]

, 1977
1. S-adenosylmethionine decarboxylase from human placenta has been purified more than 1200-fold by use of Chromatographic techniques. 2. The molecular weight was determined as approx 53,000 by gel nitration. 3.
PORTA, RAFFAELE, C. Esposito, G. Della Pietra   +2 more
core   +1 more source

Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine

Cell Stress, 2021
S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing.
Yudong Sun, Jason W. Locasale
doaj   +1 more source

Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis [PDF]

, 2013
[Background/Aim]: The aim of this study was to investigate the effects of S-adenosylmethionine on liver peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis.
Gassó, Marta, Pajares, María Ángeles, Mato, José M., Varela-Moreiras, Gregorio, Alonso Prados, Elena, Rodés, Joan   +5 more
core   +1 more source

S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review

Annals of General Psychiatry, 2020
Background Major depressive disorder (MDD) is a recurrent illness with high rates of chronicity, treatment-resistance, and significant economic impact.
Alessandro Cuomo, Bruno Beccarini Crescenzi, Simone Bolognesi, Arianna Goracci, Despoina Koukouna, Rodolfo Rossi, Andrea Fagiolini   +6 more
doaj   +1 more source

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Redox Biology, 2021
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker   +19 more
doaj   +1 more source

Phytohormonal regulation of S‐adenosylmethionine synthetase and S‐adenosylmethionine levels in dwarf pea epicotyls

FEBS Letters, 1991
A significant stimulation (2‐ to 2.5‐fold) of AdoMet synthetase was witnessed in glibberellicd acid (GA3, 1μM)‐treated epicotyls of the dwarf pea (Pisum sativum). This was accompanied by a 2.4‐fold increase in the endogenous pool of S‐adenosylmethionine. Both abscisic acid (10 μM) and cycloheximide (20 ) inhibited the GA3‐mediated enhancement of AdoMet
Mathur, Mukul, Sachar, R.C.
openaire   +2 more sources