Results 51 to 60 of about 15,844,621 (256)

The Impact of One Carbon Metabolism on Histone Methylation

Frontiers in Genetics, 2019
The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-adenosyl methionine (SAM), which is also the methyl-donating substrate of ...
Magdalini Serefidou, Anuroop Venkateswaran Venkatasubramani, Axel Imhof   +2 more
doaj   +1 more source

S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells [PDF]

, 2008
S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor
BIZZARRI, Mariano, CAVALLARO, Antonino, Cucina, Alessandra, D'ANSELMI, FABRIZIO, SCARPA, Sigfrido, FUSO, ANDREA, Cavallaro, Rosaria Adele, Cavallaro, Giuseppe   +7 more
core   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism [PDF]

, 2023
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one ...
Millington, Christopher L, Bruemmer, Kevin J, Pontel, Lucas B, Ge, Eva J, Toh, Joel DW, Esteller, Manel, Ingolia, Nicholas T, Dingler, Felix A, Pulos-Holmes, Mia C, Nomura, Daniel K, Ward, Carl C, Garcia-Prieto, Carlos A, Patel, Ketan J, Pham, Vanha N, Chang, Christopher J, Tenney, Logan   +15 more
core   +1 more source

Daropeptide natural products [PDF]

Exploration of Drug Science
Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic ...
Suze Ma, Sijia Guo, Wei Ding, Qi Zhang
doaj   +1 more source

Mini Review: Scientific Analysis of Radical S-Adenosylmethionine (SAM) Enzymes [PDF]

The radical S-Adenosylmethionine (SAM) superfamily of enzymes catalyzes a diverse range of reactions ranging from hydrogen abstraction to complicated multistep reactions such as insertions and rearrangements. The reactions they catalyze are utilized in a
Gallage H. D. N., Ariyaratne
core   +1 more source

S-Adenosylmethionine-Dependent Reduction of Lysine 2,3-Aminomutase and Observation of the Catalytically Functional Iron−Sulfur Centers by Electron Paramagnetic Resonance^† [PDF]

, 2016
Lysine 2,3-aminomutase catalyzes the interconversion of l-α-lysine and l-β-lysine. The enzyme contains an iron−sulfur cluster with unusual properties, and it requires pyridoxal-5‘-phosphate (PLP) and S-adenosylmethionine (AdoMet) for activity.
George H. Reed (2353045), Frank J. Ruzicka (2243470), Helmut Beinert (2949813), Kafryn W. Lieder (2949816), Squire Booker (2949810), Perry A. Frey (2002321)   +5 more
core   +1 more source

S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

Cell Reports, 2017
Summary: S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA and histone methylation, tuning regulation of gene expression. Appropriate intracellular SAM levels must be maintained, because methyltransferase reaction rates
Hiroki Shima, Mitsuyo Matsumoto, Yuma Ishigami, Masayuki Ebina, Akihiko Muto, Yuho Sato, Sayaka Kumagai, Kyoko Ochiai, Tsutomu Suzuki, Kazuhiko Igarashi   +9 more
doaj   +1 more source

Accumulation of S-Adenosylmethionine by Molds

Agricultural and Biological Chemistry, 1974
Aspergillus tamani accumulated about 20 μmoles of S-adenosylmethionine (SAM) in 1 g of dry cells when cultured secondarily in a medium containing more than 10 mm of l- methionine. The accumulation was not so high when l-methionine was replaced by d- methionine. Addition of nucleic acid-related substances was not effective for the accumulation. Addition
KUSAKABE, Hitoshi, KUNINAKA, Akira, YOSHINO, Hiroshi   +2 more
openaire   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source